补肝肾通络针刺法联合鲑鱼降钙素治疗急性期女性膝关节骨性关节炎的临床研究  

Clinical Study on Nourishing Kidney and Liver and Unblocking Collaterals Acupuncture Therapy Combined with Salmon Calcitonin for Acute Phase of Knee Osteoarthritis in Women

作　　者：胡谷丰[1] 陈思洁 吴三兵[1] 张芬[1] 刘洋[1] 杜国庆[3] Hu Gufeng;Chen Sijie;Wu Sanbing;Zhang Fen;Liu Yang;Du Guoqing(The Second Affiliated Hospital of Anhui University of Chinese Medicine,Anhui,Hefei 230000,China)

机构地区：[1]安徽中医药大学第二附属医院,安徽合肥230000 [2]安徽中医药大学第一附属医院,安徽合肥230000 [3]上海中医药大学附属曙光医院石氏伤科医学中心,上海201203

出　　处：《中国中医急症》2023年第3期421-424,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82174403);安徽省卫生计划生育委员会省级临床重点专科建设项目(卫科教秘〔2017〕529号)。

摘　　要：目的观察补肝肾通络针刺法联合鲑鱼降钙素治疗急性期女性膝关节骨性关节炎的有效性及安全性。方法将女性急性期膝骨性关节炎(肝肾亏虚证)患者99例按照随机数字表法分为联合组、针刺组、药物组各33例。针刺组给予补肝肾通络针刺法针刺,药物组给予鲑鱼降钙素治疗,联合组给予补肝肾通络针法联合鲑鱼降钙素治疗,连续观察2周。主要观察指标为视觉模拟量表(VAS)评分、Lysholm评分、西安大略和麦克马斯特大学骨关节炎指数膝关节评分量表(Womac)评分,次要观察指标为关节液中白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α),并进行临床疗效分析。结果治疗后各组膝关节Lysholm评分均升高(P<0.05),且联合组高于针刺组和药物组(P<0.05);各组患者VAS评分、Womac评分均下降(P<0.05),联合组明显低针刺组和药物组(P<0.05);各组关节腔内IL-6、IL-1β和TNF-α水平均下降(P<0.05),联合组较针刺组、药物组下降明显(P<0.05)。联合组总有效率明显高于针刺组、药物组(P<0.05)。结论补肝肾通络针刺法联合鲑鱼降钙素治疗女性急性期膝关节骨性关节炎能有效减轻患者疼痛,增强膝关节活动功能,提高其生活质量,并显著降低关节液中IL-6、IL-1β和TNF-α水平,且安全性较高。Objective:To investigate the clinical efficacy and safety of nourishing kidney and liver and unblocking collaterals acupuncture therapy combined with salmon calcitonin for acute phase of knee osteoarthritis in women.Methods:A total of 99 female patients with knee osteoarthritis in the acute phase who were diagnosed as deficiency were selected.These patients were divided into the combined group,acupuncture group,and medicine group according to random number table method,each with 33 cases.The acupuncture group was treated with nourishing kidney and liver and unblocking collaterals acupuncture therapy;the medicine group was treated with salmon calcitonin;the in the combined group was treated with nourishing kidney and liver and unblocking collaterals acupuncture therapy combined with salmon calcitonin.The patients were treated and continuously observed for two weeks.The main observation indexes were the visual analogue score(VAS),Lysholm Knee Score and the Western Ontario and McMaster Universities Arthritis Index(Womac);the secondary observation indexes were the interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor-necrosis-factor-α(TNF-α)in the joint fluid,and the clinical efficacy analysis was carried out.Results:After treatment,the Lysholm scores of knee joint were increased in all three groups(P<0.05),and the score in combined group was significantly higher than those in the acupuncture group and the medicine group(P<0.05).After treatment,the VAS scores and the Womac scores of the three groups decreased(P<0.05),and the scores of the combined group were significantly lower than those in the acupuncture group and the medicine group(P<0.05).The levels of IL-6,IL-1β and TNF-α of the three groups decreased,and the combined group decreased more significantly compared with the acupuncture group and medicine group(P<0.05).The results of clinical efficacy analysis showed that the combined group was statistically superior to the acupuncture group and the medicine group(P<0.05).Conclusion:Nourishing kidney and liver an

关 键 词：膝骨性关节炎 女性 补肾通络针刺法 鲑鱼降钙素 炎性因子 临床疗效 

分 类 号：R684.3[医药卫生—骨科学]