自拟补肾通络方联合丁苯酞治疗脑梗死的临床研究  

Clinical Study on Self-formulated Bushen Tongluo Decoction Combined with Butylphthalide for Patients with Cerebral Infarction

作　　者：高磊[1] 焦静[1] 张孟[1] 隋晓琳[1] 岳林 姜燕 李晗[2] 牟帅 丁玉洁[1] Gao Lei;Jiao Jing;Zhang Meng;Sui Xiaolin;Yue Lin;Jiang Yan;Li Han;Mu Shuai;Ding Yujie(Rizhao Traditional Chinese Medicine Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Shandong,Rizhao 276800,China)

机构地区：[1]山东中医药大学附属日照市中医医院,山东日照276800 [2]山东中医药大学,山东济南250355 [3]中国人民解放军总医院,北京100039

出　　处：《中国中医急症》2023年第3期428-431,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：山东省中医药科技项目青年项目(2020Q109)。

摘　　要：目的观察自拟补肾通络方联合丁苯酞对脑梗死患者神经功能、生活质量及血管生长因子、脑损伤因子的影响。方法将100例脑梗死患者随机分为试验组与对照组各50例,两组均给予西医常规治疗加丁苯酞注射液静滴,试验组在西医常规治疗的基础上合用自拟补肾通络方口服,疗程为14 d,观察记录治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、卒中后日常生活能力(Barthel)评分、脑卒中患者专用生活质量量表(SS-QOL)评分及简易生活质量量表(SF-36)评分;血清内皮生长因子(VEGF)和血管生成素-1(Ang-1)、血管生成素-2(Ang-2)水平;血清可溶性肿瘤坏死因子相关凋亡诱导配体(STRAIL)、骨保护素(OPG)、单核细胞趋化蛋白-1(MCP-1)及血清基质金属蛋白酶9(MMP-9)水平,并观察不良反应。结果治疗后,试验组NIHSS、Barthel、SS-QOL、SF-36量表的改善明显优于对照组(P<0.05);两组治疗后血清VEGF、Ang-1、Ang-2水平的上升程度,试验组均明显大于对照组(P<0.05);两组治疗后血清STRAIL、OPG、MCP-1及MMP-9水平的下降程度,试验组均大于对照组(P<0.05)。结论补肾通络方联合丁苯酞治疗脑梗死有较好的疗效,能促进神经功能恢复,提高日常活动能力,改善生活质量,同时又能提高血管生长因子、降低脑损伤因子,有助于促进侧支循环的重建、改善脑供血及脑保护的功能。Objective:To study the effects of the self-formulated Bushen Tongluo Decoction combined with butylphthalide on the neurological function,quality of life,vascular growth factor,and brain damage factor in patients with cerebral infarction.Methods:A total of 100 patients with cerebral infarction who met the standards were randomly divided into an experimental group and a control group,50 cases in each group.Both groups were given basic treatment of western medicine and butylphthalide injection intravenously.The experimental group was given the self-formulated Bushen Tongluo Decoction on the basis of basic treatment of western medicine for 14 days.The national institute of health stroke scale(NIHSS)scores,post-stroke activities of daily living(Barthel)scores,stroke patient specific quality of life scale(SS-QOL)scores,and simple quality of life scale(SF-36)scores,serum VEGF,Ang-1 and Ang-2 levels,and serum STRAIL,OPG,MCP-1,and MMP-9 levels were recorded before and after the treatment,and adverse effects were observed.Results:After treatment,the improvement of NIHSS,Barthel,SS-QOL and SF-36 scales in the experimental group was significantly better than that in the control group(P<0.05);the increase of serum VEGF,Ang-1 and Ang-2 levels in the experimental group was better than that in the control group(P<0.05);the decrease of serum STRAIL,OPG,MCP-1 and MMP-9 levels in the experimental group was better than that in the control group(P<0.05).Conclusion:Bushen Tongluo Decoction combined with butylphthalide has good efficacy in the treatment of cerebral infarction,which can promote neurological function recovery,increase daily activity ability,and improve quality of life while also increasing the vascular growth factor and decreasing the brain damage factor,which can help to promote collateral circulation reconstruction,improve brain blood supply,and the function of brain protection.

关 键 词：脑梗死 补肾通络方 丁苯酞 生活质量 血管生长因子 脑损伤因子 

分 类 号：R743.9[医药卫生—神经病学与精神病学]