苯甲酸雌二醇与戍酸雌二醇治疗无排卵型异常子宫出血的效果及对内分泌功能的影响  

Effectiveness of Estradiol Benzoate and Estradiol Garlic Acid in the Treat⁃ment of Anovulatory Abnormal Uterine Bleeding and Its Effect on Endo⁃crine Function

作　　者：曾瑞娟 黄雅容 戴泽果 ZENG Ruijuan;HUANG Yarong;DAI Zeguo(Department of Gynecology,Lufeng People's Hospital,Lufeng,Guangdong Province,516500 China)

机构地区：[1]陆丰市人民医院妇科,广东陆丰516500

出　　处：《中外医疗》2022年第32期119-123,共5页China & Foreign Medical Treatment

摘　　要：目的 研究苯甲酸雌二醇与戍酸雌二醇治疗无排卵型异常子宫出血的效果及对内分泌功能影响。方法 随机选取2020年2月—2021年6月间陆丰市人民医院收治的80例无排卵型异常子宫出血患者,根据1∶1比例随机分成研究组和对照组,分别给予苯甲酸雌二醇、戍酸雌二醇治疗。比较两组患者止血情况、排卵及规律月经情况、临床疗效,血清黄体生成素(LH)、促卵泡生成素(FSH)、雌激素(E2)水平以及不良反应情况。结果 研究组控制出血时间、完全止血时间分别为(12.64±3.23)h、(26.14±6.74)h,均短于对照组,差异有统计学意义(t=9.811、4.074,P<0.001)。研究组超声下有卵、规律月经占比分别为75.00%、97.50%,均高于对照组,差异有统计学意义(χ^(2)=5.333、4.507,P=0.021、0.034)。研究组总有效率为97.50%,高于对照组,差异有统计学意义(χ^(2)=4.507,P=0.034)。治疗后,两组血清LH、FSH水平均低于治疗前,且研究组血清LH、FSH水平分别为(29.57±3.12)U/L、(28.53±3.31)U/L,低于对照组,差异有统计学意义(t=7.786、11.340,P<0.001)。治疗后,两组E2水平高于治疗前,且研究组E2水平为(296.48±36.82)pmol/L,高于对照组,差异有统计学意义(t=15.090,P<0.001)。研究组不良反应总发生率为5.00%,低于对照组,差异有统计学意义(χ^(2)=6.275,P=0.012)。结论 苯甲酸雌二醇用于无排卵型异常子宫出血的治疗更有利于提高临床疗效,同时能有效缩短控制出血时间、完全止血时间,提高超声下有卵、规律月经的占比及内分泌功能,且安全性佳。Objective To study the effect of estradiol benzoate and estradiol garlic acid in the treatment of anovulatory abnormal uterine bleeding and the effect on endocrine function.Methods Eighty patients with anovulatory abnormal uterine bleeding admitted to Lufeng People's Hospital from February 2020 and June 2021 were randomly selected.The patients were randomly divided into study group and control group according to 1:1 ratio,and were treated with es⁃tradiol benzoate and estradiol garlicate,respectively.The hemostasis,ovulation and regular menstruation,clinical effi⁃cacy,serum luteinizing hormone(LH),folliculopoietin(FSH),estrogen(E 2)levels,and adverse effects were compared between the two groups.Results The controlled bleeding time and complete hemostasis time in the study group were(12.64±3.23)h and(26.14±6.74)h,shorter than those in the control group,the difference was statistically significant(t=9.811,4.074,P<0.001).The percentage of having eggs and regular menstruation under ultrasound was 75.00%、97.50%in the study group,which were higher than those in the control group,the difference was statistically significant(χ^(2)=5.333,4.507,P=0.021,0.034).The total effective rate of the study group was 97.50%,higher than that of the control group,the difference was statistically significant(χ^(2)=4.507,P=0.034).After treatment,the serum LH and FSH levels were lower in both groups than before treatment,and the serum LH and FSH levels in the study group were(29.57±3.12)U/L and(28.53±3.31)U/L,lower than those in the control group,the difference was statistically signifi⁃cant(t=7.786,11.340,P<0.001).After treatment,E2 levels were higher in both groups than before treatment,and E2 levels in the study group were(296.48±36.82)pmol/L,higher than that in the control group,the difference was statisti⁃cally significant(t=15.090,P<0.001).The overall incidence of adverse reactions in the study group was 5.00%,which was lower than that in the control group,the difference was statistically significant(χ^(2)=6.275,P=0

关 键 词：苯甲酸雌二醇 戍酸雌二醇 无排卵型异常子宫出血 

分 类 号：R563[医药卫生—呼吸系统]