模板法合成ZnO中空介孔纳米粒子及其负载抗癌药物的应用研究  

Template synthesis of ZnOhollowmesoporous nanoparticles and their application in anticancer drug delivery

作　　者：施寒竹 尹登科[2] SHI Han-zhu;YIN Deng-ke(Medical and Health Testing Centre,Anhui Academy of Medical Sciences,Hefei 230031,China;Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Anhui University of Chinese Medicine,Hefei 230012,China)

机构地区：[1]安徽省医学科学研究院医药卫生检测中心,安徽合肥230031 [2]安徽中医药大学药物制剂技术与应用安徽省重点实验室,安徽合肥230012

出　　处：《化学研究与应用》2023年第3期684-690,共7页Chemical Research and Application

基　　金：药物制剂技术与应用安徽省重点实验室开放基金资助项目(2021KFKT02)资助。

摘　　要：无机纳米材料因制备条件较为温和、具有独特的理化性质及良好的生物相容性常被应用于生物领域,尤其在药物运输方面有着极大的优势,然而,低载药量和药物无效释放是限制无机纳米粒子用作药物运输载体的两大重要因素。本文,我们构建出一种简便的合成方法,以聚丙烯酸钠纳米粒子为模板,通过引入锌盐,成功合成出具备较好分散性和稳定性的ZnO中空介孔纳米粒子,分别考察了其载药、药物释放和生物相容性等方面的性质。载药实验结果显示合成的ZnO中空介孔纳米粒子对抗癌药物盐酸阿霉素的负载量和负载效率分别高达49%和98%。药物缓释实验证明该纳米粒子具有pH响应药物缓释性能,与中性环境相比,该载药体系在类肿瘤的弱酸性环境中有着更高的药物释放量和释放速率。细胞毒性实验证实该纳米粒子具有极低的毒性和良好的生物相容性。Inorganic nanomaterials are often used in the biological field because of their mild preparation conditions,unique physicochemical properties and good biocompatibility,especially in drug transportation.However,low drug loading and ineffective drug release are two important factors limiting the use of inorganic nanoparticles as drug delivery carriers.In this paper,we constructed a simple methodto synthesis ZnO hollow mesoporous nanoparticles byusing poly(acrylic acid)sodium(PAAS)as templates and introducing zinc salts into the reaction system,which have good dispersion and stability.The properties of drug loading,drug release and biocompatibility were investigated,respectively.The drug loading experiments showed that the obtained ZnO hollow mesoporous nanoparticles exhibited loading content and encapsulation efficiency of the anticancer drug doxorubicin(DOX)as high as 49%and 98%,respectively.The drug release experiment proved that the nanoparticles had pH-responsive drug sustained release property.Compared with physiologically neutral pH environment,this drug-loaded system had higher drug release amount and rate in the mildly acidic environment of tumor-like.Cytotoxicity experiments confirmed that the nanoparticles had extremely low toxicity and good biocompatibility.

关 键 词：ZNO纳米粒子 中空 介孔 pH响应药物缓释 药物运输 

分 类 号：O614.2[理学—无机化学]