定量降低主食血糖负荷疗法联合运动疗法对妊娠期糖尿病患者血糖控制效果及BMI变化的影响  

Effects of Quantitative Reduction of Staple Food Glycemic Load Therapy Combined with Exercise Therapy on Glycemic Control and BMI Changes in Gestational Diabetes Mellitus

作　　者：林柏珠 丘馥微 LIN Bozhu;QIU Fuwei(Department of Obstetrics,Longyan People's Hospital,Longyan,Fujian Province,364000 China)

机构地区：[1]福建省龙岩人民医院产科,福建龙岩364000

出　　处：《糖尿病新世界》2022年第24期18-22,共5页Diabetes New World Magazine

摘　　要：目的探究在妊娠期糖尿病(Gestational diabetes mellitus,GDM)中采用定量降低主食血糖负荷疗法联合运动疗法对血糖控制效果及体质量指数(body mass index,BMI)的影响。方法选择2021年2月—2022年3月福建龙岩人民医院产科收治的82例GDM患者作为研究对象,按随机数表法分为对照组和观察组,每组41例。对照组采取常规干预,观察组在此基础上采取定量降低主食血糖负荷疗法联合运动疗法,均持续干预至分娩前,比较两组血糖水平、BMI、胰岛细胞功能、妊娠结局。结果对比两组干预前血糖水平、胰岛细胞功能,差异无统计学意义(P>0.05);观察组干预后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)水平均低于对照组,孕期BMI增加、平均每周BMI增加均低于对照组,空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均低于对照组,胰岛β细胞分泌功能指数(HOMA-β)较对照组高,差异有统计学意义(P<0.05)。与对照组(19.51%)不良妊娠结局发生率相比,观察组(4.88%)较低,差异有统计学意义(P<0.05)。结论定量降低主食血糖负荷疗法联合运动疗法能够有效调节GDM患者血糖水平,改善孕妇体质量及胰岛细胞功能,降低不良妊娠结局发生率。Objective To explore the influence of quantitative reduction of staple food glycemic load therapy com⁃bined with exercise therapy on blood glucose control effect and body mass index(BMI)in gestational diabetes mellitus(GDM).Methods A total of 82 patients with GDM admitted to the Department of Obstetrics of Longyan People's Hospi⁃tal from February 2021 to March 2022 were selected as the research object and divided into control group and observa⁃tion group according to random number table method,with 41 cases in each group.The control group received routine intervention,and the observation group received quantitative reduction of staple food glycemic load therapy combined with exercise therapy on this basis,and continued intervention until delivery.Blood glucose level,BMI,islet cell func⁃tion and pregnancy outcome were compared between the two groups.Results There was no significant difference in blood glucose level and islet cell function between the two groups before intervention(P>0.05);after intervention,the levels of fasting blood glucose(FPG),2-hour postprandial blood glucose(2 hPG)and glycated hemoglobin A1c(HbA1c)in the observation group were lower than those in the control group.Pregnancy BMI increases and mean weekly BMI increases were lower than those in the control group.Fasting insulin(FINS)and Homeostasis Model Assessment-Insulin Resistance(HOMA-IR)were lower than those of the control group.Homeostasis model assessment-β(HOMA-β)was higher than that of control group,and the difference was statistically significant(P<0.05).Compared with the control group(19.51%),the incidence of adverse pregnancy outcome in the observation group(4.88%)was lower,and the difference was statistically significant(P<0.05).Conclusion Quantitative reduction of staple food glycemic load therapy combined with exercise therapy can effectively regulate blood glucose level in patients with GDM,improve body weight and islet cell function in pregnant women,and reduce the incidence of adverse pregnancy outcomes.

关 键 词：妊娠期糖尿病 定量降低主食血糖负荷疗法 运动疗法 血糖 体质指数 胰岛细胞功能 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]