IL-6和IL-1β与AMI心力衰竭病人心功能相关性  

CORRELATION OF INTERLEUKIN-6 AND INTERLEUKIN-1βWITH CARDIAC FUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND HEART FAILURE

作　　者：唐锡龙 王海燕[1] 徐从凤 宋冰雪 刘鑫[1] 李永红 TANG Xilong;WANG Haiyan;XU Congfeng;SONG Bingxue;LIU Xin;LI Yonghong(Department of Cardiology,The Affiliated Hospital of Qingdao University,Qingdao 266100,China)

机构地区：[1]青岛大学附属医院心血管内科,山东青岛266100

出　　处：《青岛大学学报（医学版）》2023年第1期93-96,共4页Journal of Qingdao University(Medical Sciences)

基　　金：山东省重点研发项目(2018GSF118241);中华国际医学交流基金会心血管多学科整合思维研究基金(Z-2016-23-2001-25);青大附院临床医学+科研项目(QDFY+X20210-51);山东省老年医学学会科技攻关计划(LKJGG2021W076)。

摘　　要：目的探讨炎症因子白细胞介素6(IL-6)、白细胞介素1β(IL-1β)与急性心肌梗死(AMI)并发心力衰竭(心衰)病人心功能下降程度的相关性。方法连续选取2021年6月—2022年3月就诊于青岛大学附属医院崂山院区的AMI病人120例,分为心衰组和非心衰组各60例。于发病第2天检测病人血浆N末端B型脑钠肽(NT-proBNP)、IL-6、IL-1β水平,心脏超声检查左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV),并对这些数据进行组间比较及相关性分析。结果与非心衰组比较,心衰组的LVEF下降,NT-proBNP升高,差异有统计学意义(Z=-8.129、-4.325,P<0.05);两组LVEDV、LVESV差异无统计学意义(P>0.05)。心衰组IL-6水平较非心衰组明显升高(Z=-3.155,P<0.05);两组病人的IL-6水平与NT-proBNP水平呈正相关(r=0.290,P<0.05),与LVEF呈负相关(r=-0.275,P<0.05)。两组病人的IL-1β水平差异无统计学意义,且与NT-proBNP、LVEF无明显相关性(P>0.05)。两组病人的IL-1β、IL-6水平与LVESV、LVEDV均无明显相关性(P>0.05)。结论AMI并发心衰病人IL-6水平明显升高,且IL-6水平与心功能下降程度相关,而IL-1β水平与心功能下降程度无明显相关性。提示IL-6在AMI后心衰的发生发展过程中起着重要作用,针对IL-6的治疗在预防AMI后心衰方面具有潜在价值。Objective To investigate the correlation of the inflammatory factors interleukin-6(IL-6)and interleukin-1β(IL-1β)with the degree of reduction in cardiac function in patients with acute myocardial infarction(AMI)and heart failure.Methods A total of 120 patients with AMI who attended Laoshan Branch of The Affiliated Hospital of Qingdao University from June 2021 to March 2022 were enrolled and divided into heart failure group and non-heart failure group,with 60 patients in each group.The plasma levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),IL-6,and IL-1βwere measured on day 2 after disease onset,and cardiac ultrasound was used to measure left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),and left ventricular end-diastolic volume(LVEDV).These data were compared between groups,and a correlation analysis was performed.Results Compared with the non-heart failure group,the heart failure group had a significant reduction in LVEF and a significant increase in NT-proBNP(Z=-8.129,-4.325;P<0.05),while there were no significant differences in LVEDV and LVESV between the two groups(P>0.05).The heart failure group had a significantly higher level of IL-6 than the non-heart failure group(Z=-3.155,P<0.05),and the level of IL-6 was positively correlated with NT-proBNP(r=0.290,P<0.05)and negatively correlated with LVEF(r=-0.275,P<0.05)in both groups.There was no significant difference in the level of IL-1βbetween the two groups,and there was no significant correlation between IL-1βand NT-proBNP/LVEF(P>0.05).The levels of IL-1βand IL-6 were not significantly correlated with LVESV and LVEDV in the heart failure group and the non-heart failure group(P>0.05).Conclusion There is a significant increase in the level of IL-6 in patients with AMI and heart failure,and the level of IL-6 is correlated with the degree of reduction in cardiac function,while there is no significant correlation between the level of IL-1βand the degree of reduction in cardiac function.These results suggest th

关 键 词：心肌梗死 心力衰竭 白细胞介素6 白细胞介素1Β 心脏功能试验 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]