葛根素对脑缺血保护作用及其机制的研究进展  

RESEARCH ADVANCES IN THE PROTECTIVE EFFECT OF PUERARIN AGAINST CEREBRAL ISCHEMIA AND ITS MECHANISM

作　　者：金明睿 张梅[1] JIN Mingrui;ZHANG Mei(School of Basic Medicine,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学基础医学院,山东青岛266071

出　　处：《青岛大学学报（医学版）》2023年第1期155-158,共4页Journal of Qingdao University(Medical Sciences)

摘　　要：葛根素是葛根总黄酮的主要单体成分之一,是一种异黄酮类植物雌激素,具有重要的药理作用,且不良反应小、安全性高。据报道,葛根素具有多种药理活性,包括抗炎、抗氧化应激、抗凋亡、抗自噬等作用,有益于缓解脑缺血再灌注损伤以及缺血性脑血管疾病的治疗。本文主要对近些年来葛根素在脑缺血再灌注损伤中的保护作用机制研究进行综述,以期为葛根素的进一步研究提供依据和思路。Puerarin,one of the main monomer components of total flavonoids in Radix Puerariae,is an isoflavone phytoestrogen with important pharmacological actions,few adverse reactions,and high safety.It has been reported that puerarin has a variety of pharmacological activities,including anti-inflammatory,anti-oxidative stress,anti-apoptosis,and anti-autophagy effects,and may help with the alleviation of cerebral ischemia-reperfusion injury and the treatment of ischemic cerebrovascular diseases.This article reviews the research advances in the mechanism of the protective effect of puerarin against cerebral ischemia/reperfusion injury in recent years,in order to provide a basis and ideas for further research on puerarin.

关 键 词：葛根素 脑缺血 神经保护 综述 

分 类 号：R285.5[医药卫生—中药学] R743.31[医药卫生—中医学]