金石清肺口服液治疗小儿急性支气管炎痰热壅肺证临床疗效及对血清炎症因子水平的影响  

Clinical efficacy of Jinshi Qingfei oral liquid for children with acute bronchitis of lung phlegm heat syndrome and its influence on serum inflammatory factors

作　　者：聂金涛[1] 李章立[1] 郑玮[1] 刘超 李学明[1] NIE Jintao;LI Zhangli;ZHENG Wei;LIU Chao;LI Xueming(Department of Pediatrics,Handan Hospital of Traditional Chinese Medicine,Handan,Hebei 056000)

机构地区：[1]河北省邯郸市中医院儿科,河北邯郸056000

出　　处：《河北中医》2023年第2期208-211,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2019年度中医药类科研计划课题(编号:2019382)。

摘　　要：目的观察金石清肺口服液治疗小儿急性支气管炎痰热壅肺证的临床疗效。方法将120例急性支气管炎痰热壅肺证患儿按照随机数字表法分为2组,对照组60例予阿奇霉素肠溶胶囊治疗,治疗组60例予金石清肺口服液治疗。2组均治疗1周后统计疗效,比较2组患儿治疗前后咳嗽及咯痰评分变化情况,比较2组治疗前后肺功能第1 s用力呼气容积(FEV_(1))及第1 s用力呼气容积占预计值的百分比(FEV_(1)%)变化情况,比较2组治疗前后血清炎症因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及超敏C反应蛋白(hs-CRP)水平变化情况,比较2组患儿治疗期间不良反应发生情况。结果治疗组总有效率98.3%(59/60),不良反应总发生率3.33%(2/60),对照组总有效率90.0%(54/60),不良反应总发生率11.67(7/60),治疗组总有效率高于对照组(P<0.05),不良反应总发生率低于对照组(P<0.05)。与本组治疗前比较,2组治疗后咳嗽及咯痰评分均降低(P<0.05),且治疗组治疗后咳嗽及咯痰评分均低于对照组(P<0.05)。与本组治疗前比较,治疗组治疗后FEV_(1)%水平升高(P<0.05),FEV_(1)虽然也有升高趋势但比较差异无统计学意义(P<0.05),对照组治疗前后FEV_(1)及FEV_(1)%水平比较差异均无统计学意义(P>0.05),2组治疗后FEV_(1)及FEV_(1)%组间比较差异均无统计学意义(P>0.05)。与本组治疗前比较,2组治疗后血清TNF-α、IL-6及hs-CRP水平均降低(P<0.05),且治疗组治疗后TNF-α水平低于对照组(P<0.05)。结论金石清肺口服液治疗小儿急性支气管炎临床疗效显著,不良反应发生率较低,其作用机制与降低血清炎症因子水平,改善肺功能有关。Objective To observe the clinical efficacy of Jinshi Qingfei oral liquid for children with acute bronchitis(lung phlegm heat syndrome).Methods Totally 120 children with acute bronchitis(lung phlegm heat syndrome)were randomly assigned to the control group(n=60)and the treatment group(n=60),in which they were treated with azithromycin enteric capsule and Jinshi Qingfei oral liquid,respectively.A 1-week treatment was performed to compare the scores of cough and expectoration,forced expiratory volume in the first second(FEV_(1)),the percentage of the predicted forced expiratory volume in one second(FEV_(1)%),serum inflammatory factors(tumor necrosis factor-α[TNF-α],interleukine-6[IL-6],high-sensitive C-reactive protein[hs-CRP]).The curative effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(98.3%[59/60]vs 90.0%[54/60],[P<0.05],respectively).The total incidence of adverse reactions was lower in the treatment group(3.33%[2/60])compared with the control group(11.67%[7/60]),(P<0.05).After treatment,the scores of cough and expectoration in groups were decreased(P<0.05),which were decreased in the treatment group compared with the control group(P<0.05).The level of FEV_(1)%in the treatment group was increased after treatment compared with before treatment(P<0.05),FEV_(1) tended to increase,but with no statistically significant difference(P<0.05).The difference was not statistically significant in FEV_(1) and FEV_(1)%in the control group before and after treatment(P>0.05).None of the FEV_(1) and FEV_(1)%differed significantly between groups(P>0.05).TNF-α,IL-6 and hs-CRP in groups were decreased,TNF-αwas lower in the treatment group than in the control group(P<0.05).Conclusion For children with acute bronchitis,Jinshi Qingfei oral liquid has significant clinical curative effect,can improve lung function by reducing serum inflammatory factors,and decrease the incidence of adverse reactions.

关 键 词：急性支气管炎 儿童疾病 中药疗法 

分 类 号：R289.6[医药卫生—方剂学]