苗医弩药针疗法辅助治疗肺癌疼痛:随机对照试验  

Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain:a randomized controlled trial

作　　者：陈慧 吴文宇 谢贞明 杨柱 杨兵 唐东昕 CHEN Hui;WU Wen-yu;XIE Zhen-ming;YANG Zhu;YANG Bing;TANG Dong-xin(First Clinical Medical College of Guizhou University of TCM,Guiyang 550002,China;Department of Oncology,First Affiliated Hospital of Guizhou University of TCM,Guiyang 550001)

机构地区：[1]贵州中医药大学第一临床医学院,贵阳550002 [2]贵州中医药大学第一附属医院肿瘤科,贵阳550001

出　　处：《中国针灸》2023年第3期322-326,共5页Chinese Acupuncture & Moxibustion

基　　金：国家重点研发计划项目:2019YFC1712500;贵州省科技计划项目:黔科合平台人才[2020]5013、黔科合后补助[2020]3003;国家自然科学基金后补助资金科研创新探索专项项目:2019YFC171250402;贵州中医药大学研究生教育创新计划项目:YCXZR2020007。

摘　　要：目的:观察在盐酸羟考酮缓释片基础上,苗医弩药针疗法辅助治疗肺癌疼痛的临床疗效。方法:将60例肺癌疼痛患者随机分为观察组(30例,脱落1例)和对照组(30例)。对照组予口服盐酸羟考酮缓释片,每次10 mg,每12小时1次;观察组在对照组基础上予苗医弩药针疗法,隔日1次,两组均治疗14 d。分别于治疗前后观察两组患者疼痛数字量表(NRS)评分、爆发痛次数、Karnofsky功能状态量表(KPS)评分,记录两组患者等效羟考酮消耗量、不良反应发生率,并比较两组患者镇痛疗效。结果:与治疗前比较,两组患者治疗后NRS评分降低、爆发痛次数减少、KPS评分升高(P<0.01);治疗后,观察组患者NRS评分低于对照组(P<0.01),爆发痛次数少于对照组(P<0.01),KPS评分高于对照组(P<0.05)。观察组患者全程等效羟考酮消耗量及便秘、嗜睡、恶心呕吐不良反应发生率低于对照组(P<0.05)。观察组患者镇痛有效率为93.1%(27/29),高于对照组的63.3%(19/30,P<0.05)。结论:在盐酸羟考酮缓释片基础上,苗医弩药针疗法辅助治疗可有效减轻肺癌疼痛患者疼痛程度、减少爆发痛次数,改善患者健康状况及生活质量,增加药物疗效并减少不良反应。Objective To observe the clinical efficacy of Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain based on oxycodone hydrochloride extended-release tablet.Methods A total of 60 patients with lung cancer pain were randomized into an observation group(30 cases,1 case dropped off)and a control group(30 cases).In the control group,oxycodone hydrochloride extended-release tablet was given orally,10 mg a time,once every 12 hours.On the basis of the treatment in the control group,Miao medicinal crossbow acupuncture therapy was applied once every other day in the observation group.The treatment of 14 days was required in the two groups.Before and after treatment,the numerical rating scale(NRS)score,number of break-out pain and Karnofsky performance status(KPS)score were observed in the two groups.The equivalent oxycodone consumption and rate of adverse reactions were recorded,the analgesic effect was evaluated in the two groups.Results Compared before treatment,the NRS scores and number of break-out pain were decreased while the KPS scores were increased after treatment in the two groups(P<0.01).After treatment,the NRS score and number of break-out pain in the observation group were lower than the control group(P<0.01),the KPS score in the observation group was higher than the control group(P<0.05).The equivalent oxycodone consumption of whole course and the rate of adverse reactions i.e.constipation,drowsiness,nausea and vomiting in the observation group were lower than the control group(P<0.05).The analgesic effect rate was 93.1%(27/29)in the observation group,which was superior to 63.3%(19/30)in the control group(P<0.05).Conclusion On the basis of oxycodone hydrochloride extended-release tablet,Miao medicinal crossbow acupuncture therapy as adjuvant treatment can effectively relieve the pain degree,reduce the number of break-out pain and improve the health status and quality of life in patients with lung cancer pain,enhance the efficacy of medication and reduce its adverse reactions.

关 键 词：肺癌 疼痛 苗医弩药针疗法 盐酸羟考酮缓释片 药物不良反应 

分 类 号：R245.316[医药卫生—针灸推拿学]