一石二鸟:镍催化烯烃不对称氢烷基化构建相邻sp^(3)碳立体中心  

Two birds with one stone:asymmetric construction of vicinal C(sp^(3))centres by nickel-catalyzed hydroalkylation of alkenes

作　　者：廖港 史炳锋 Gang Liao;Bing-Feng Shi(Department of Chemistry,Zhejiang University,Hangzhou 310027,China;College of Biological,Chemical Science and Engineering,Jiaxing University,Jiaxing 314001,China)

机构地区：[1]Department of Chemistry,Zhejiang University,Hangzhou 310027,China [2]College of Biological,Chemical Science and Engineering,Jiaxing University,Jiaxing 314001,China

出　　处：《Science Bulletin》2023年第5期462-464,共3页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(21925109 and U22A20388).

摘　　要：The construction of chiral C(sp^(3))-rich molecules is of great interest in natural products synthesis and drug discovery.To fulfill the requirement of chiral C(sp^(3))-rich molecules,various approaches have been developed recently.Among these elegant approaches,nickel-catalyzed asymmetric C(sp^(3))-C(sp^(3))cross-coupling has emerged as one of the most appealing approaches,which enables the enantioselective coupling between divergent racemic alkyl electrophiles and racemic alkyl nucleophiles[1,2].

关 键 词：COUPLING ALKYL CHIRAL 

分 类 号：O621[理学—有机化学]