清胃和中汤辅助治疗小儿幽门螺杆菌感染脾胃湿热证47例临床观察  

Clinical observation on 47 cases of helicobacter pylori infection in children with spleen and stomach dampness-heat syndrome treated by Qingwei Hezhong Tang(清胃和中汤)as adjuvant therapy

作　　者：赵西斌[1] 吴山永 ZHAO Xibin;WU Shanyong(Department of Pediatrics,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing,Zhejiang,314000,China;Department of TCM Internal Medicine,The Second Hospital of Jiaxing,Jiaxing,Zhejiang,314000,China)

机构地区：[1]嘉兴市中医医院儿科,浙江嘉兴314000 [2]嘉兴市第二医院中医内科,浙江嘉兴314000

出　　处：《中医儿科杂志》2023年第1期51-55,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2020ZB252)。

摘　　要：目的观察清胃和中汤辅助治疗小儿幽门螺杆菌(Hp)感染脾胃湿热证的临床疗效。方法选取2018年7月至2020年7月在嘉兴市中医医院儿科收治的94例Hp感染脾胃湿热证患儿,按照随机数字表法分为治疗组和对照组,各47例。对照组给予阿莫西林胶囊、奥美拉唑肠溶胶囊、甲硝唑片、克拉霉素序贯疗法治疗,治疗组在对照组治疗方法的基础上予清胃和中汤口服,2组均治疗10 d后统计疗效。结果对照组总有效率为76.60%(36/47),治疗组为95.74%(45/47),2组比较,差异有统计学意义(P<0.05)。对照组Hp根除率为65.96%(31/47),治疗组为82.98(39/47),2组比较,差异有统计学意义(P<0.05)。治疗前2组主、次症积分和中医证候总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组各项积分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05或P<0.01),且治疗组下降更显著(P<0.05)。治疗前,2组肠道各种菌群落数比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组乳酸杆菌、双歧杆菌明显升高,肠杆菌、肠球菌明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或下降更显著(P<0.05)。结论清胃和中汤辅助治疗小儿Hp感染脾胃湿热证疗效显著,可提高Hp根除率,改善患儿临床症状,调节肠道菌群,值得临床推广应用。Objective To observe the clinical effect of Qingwei Hezhong Tang(清胃和中汤)in adjuvant treatment of helicobacter pylori(Hp)infection in children with spleen and stomach damp-heat syndrom.Methods A total of 94 children with Hp infection admitted to the Department of Pediatrics,Jiaxing Hospital of Traditional Chinese Medicine from July 2018 to July 2020 were divided into a treatment group and a control group using a random number table,with 47 cases in each group.The control group was treated with amoxicillin capsule,omeprazole enteric-coated capsule,metronidazole tablets and clarithromycin sequential therapy.On the basis of the treatment method of the control group,Qingwei Hezhong Tang was taken orally by the treatment group.We kept statistics about the efficacy of the two groups after 10 days of treatment.Results The total effective rate was 76.60%(36/47)in the control group and 95.74%(45/47)in the treatment group,the difference being significant(P<0.05).The Hp eradication rate was 65.96%(31/47)in the control group and 82.98%(39/47)in the treatment group,the difference being significant(P<0.05).There was no significant difference in the scores of primary and secondary symptoms and the total scores of TCM syndromes between the two groups before treatment(P>0.05),indicating that they were comparable.After treatment,all the above scores in the two groups were decreased significantly,the difference was statistically significant in the same group(P<0.05 or P<0.01),and the decrease in the treatment group was more significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the number of intestinal bacterial communities between the two groups(P>0.05),and they were comparable.After treatment,the levels of lactobacillus and bifidobacteria in the two groups were increased significantly,while the levels of enterobacteria and enterococcus were decreased significantly(P<0.05),and the increase or decrease in the treatment group was more significant(P<0.05).Conclusion Qingwei H

关 键 词：小儿 幽门螺杆菌 脾胃湿热证 清胃和中汤 临床观察 

分 类 号：R256.3[医药卫生—中医内科学]