滋阴泻火方辅助治疗女童特发性中枢性性早熟阴虚火旺证43例临床观察  

Clinical observation on 43 cases of idiopathic central precocious puberty in girls with flaring of fire due to yin-deficiency syndrome treated by Ziyin Xiehuo Fang(滋阴泻火方)as adjuvant therapy

作　　者：陆建卫 LU Jianwei(Department of Pediatrics,The First People's Hospital of Pinghu,Pinghu,Zhejiang,314200,China)

机构地区：[1]平湖市第一人民医院儿科,浙江平湖314200

出　　处：《中医儿科杂志》2023年第1期69-73,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察滋阴泻火方辅助治疗女童特发性中枢性性早熟(ICPP)阴虚火旺证的临床疗效。方法选取2019年1月至2021年4月平湖市第一人民医院儿科收治的女童ICPP阴虚火旺证患儿85例,以数字奇偶法分为对照组42例和治疗组43例。对照组给予注射用醋酸亮丙瑞林缓释微球肌肉注射,治疗组在对照组治疗方法的基础上给予滋阴泻火方治疗,2组均以3个月为1个疗程,治疗1个疗程后统计临床疗效。结果对照组总有效率为80.95%(34/42),治疗组为95.35%(41/43),2组比较,差异有统计学意义(P<0.05)。治疗前2组子宫、卵巢容积和乳核直径比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标均明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组黄体生成素(LH)、卵泡促激素(FSH)及雌二醇(E2)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组LH、FSH、E2水平均显著下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。对照组不良反应总发生率为11.90%(5/42),治疗组为6.98%(3/43),2组比较,差异无统计学意义(P>0.05)。结论滋阴泻火方辅助治疗女童ICPP阴虚火旺证疗效确切,能明显改善患儿第二性征发育,降低性激素水平,且药物不良反应较小,值得临床推广应用。Objective To observe the clinical efficacy of Ziyin Xiehuo Fang(滋阴泻火方)as adjuvant therapy in the treatment of girls with idiopathic central precocious puberty(ICPP)with flaring of fire due to yin-deficiency syndrome.Methods 85 cases of ICPP girls with flaring of fire due to yin-deficiency syndrome admitted to the Department of Pediatrics in The First People’s Hospital of Pinghu from January 2019 to January 2021 were divided into a treatment group with 43 cases and a control group with 42 cases by digital parity method.The control group was given intramuscular injection of leprerelin acetate sustained release microspheres,on this basis,the treatment group was given Ziyin Xiehuo Fang.Both groups were consecutively treated for 3 months as 1 course of treatment,and the clinical efficacy was evaluated after 1 course of treatment.Results The total effective rate of the control group was 80.95%(34/42),that of the treatment group was 95.35%(41/43),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in uterine size,ovarian volume and follicle diameter between the 2 groups(P>0.05),and they were comparable.After treatment,uterine size,ovarian volume and follicle diameter significantly reduced,and the difference was statistically significant compared with the same group before treatment(P<0.05).Before treatment,there was no significant difference in the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E2)between the two groups before treatment(P>0.05),and they were comparable;After treatment,the levels of LH,FSH and E2 in the two groups were significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the decrease in the treatment group was more significant(P<0.05).The incidence of adverse reactions was 11.90%(5/42)in the control group and 6.98%(3/43)in the treatment group.There was no statistical significance between

关 键 词：女童 特发性中枢性性早熟 阴虚火旺证 滋阴泻火方 临床观察 

分 类 号：R725.8[医药卫生—儿科]