成年男性吸烟者中脑腹侧被盖区静息态功能连接的功能磁共振成像研究  

Resting-state functional connectivity alterations of ventral tegmental area in adult male smokers:a functional magnetic resonance imaging study

作　　者：张孟哲 高昕宇 杨镇圭 牛晓玉 汪卫建 许珂[1] 程敬亮[1] 张勇[1] Zhang Mengzhe;Gao Xinyu;Yang Zhengui;Niu Xiaoyu;Wang Weijian;Xu Ke;Cheng Jingliang;Zhang Yong(Department of MRI,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《中华行为医学与脑科学杂志》2023年第1期31-36,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200381)。

摘　　要：目的探讨成年男性吸烟者中脑腹侧被盖区(ventral tegmental area,VTA)和黑质(substantia nigra,SN)与全脑静息态功能连接的异常改变,及其与吸烟临床特征的相关性。方法回顾性分析2014年1月至2018年12月招募的131名受试者的静息态功能磁共振数据,其中长期吸烟者(吸烟组)76名,不吸烟者(对照组)55名。选取VTA/SN为种子点,计算VTA/SN与全脑的静息态功能连接(resting-state functional connectivity,RSFC)。基于SPM 12软件,采用独立样本t检验比较吸烟组和对照组RSFC的差异。使用SPSS 22.0软件,采用Pearson相关分析吸烟组RSFC的变化与尼古丁依赖量表(Fagerström test for nicotine dependence,FTND)得分、吸烟指数的相关性。结果与对照组相比,吸烟组VTA与默认网路(default mode network,DMN)相关脑区(后扣带回皮层、右侧楔前叶、双侧颞上回、右侧颞中回、右侧顶下小叶)、边缘系统(右侧边缘叶、右侧角回)、右侧距状裂周围皮层(MNI:x,y,z=24,-55,-14)、左侧岛叶(MNI:x,y,z=-35,-11,9)的RSFC较对照组显著降低(GRF校正,体素水平P<0.005,团块水平P<0.05)。以SN为种子点,吸烟组与对照组相比差异无统计学意义(P>0.05)。VTA-左侧颞上回RSFC与吸烟指数、FTND呈正相关(r=0.243,P=0.034;r=0.282,P=0.014)。VTA-左侧岛叶RSFC与FTND呈正相关(r=0.316,P=0.006)。结论成年男性吸烟者中脑边缘系统内及VTA-DMN回路RSFC存在异常改变,这种改变在一定程度上可解释吸烟者奖赏缺乏和情绪调节功能障碍,可为进一步理解烟草成瘾机制提供线索。Objective To investigate the alterations of resting-state functional connectivity(RSFC)in ventral tegmental area(VTA)and substantia nigra(SN)among male smokers,and its correlation with clinical characteristics of smoking.Methods The resting-state functional magnetic resonance data of 131 subjects recruited from January 2014 to December 2018 were analyzed retrospectively,including 76 smokers(smoking group)and 55 non-smokers(control group).VTA/SN was selected as regions of interest(ROI),and then calculated RSFC between VTA/SN and the whole brain.Based on SPM12 software,independent sample t-test was conducted to compare the differences in RSFC between smoking group and control group.Based on SPSS 22.0 software,Pearson correlation analysis was used to investigate the relationships between the RSFC of brain regions with significant differences and Fagerström test for nicotine dependence(FTND)score,pack-year of smokers.Results Compared with control group,the results showed decreased RSFC between VTA and the brain regions related default mode network(DMN)(including posterior cingulate cortex,right anterior cuneiform lobe,bilateral superior temporal gyrus,right middle temporal gyrus and right inferior parietal lobule),and regions of limbic system(including right marginal lobe and right angular gyrus),right calcarine(MNI:x,y,z=24,-55,-14)and left insula(MNI:x,y,z=-35,-11,9)in smoking group(GRF corrected,voxel level P<0.005,cluster level P<0.05).Taking SN as the seed,there was no significant difference between smoking group and control group(P>0.05).RSFC of VTA-left superior temporal gyrus was positively correlated with pack-year(r=0.243,P=0.034)and FTND(r=0.282,P=0.014).VTA-left insula RSFC was positively correlated with FTND(r=0.316,P=0.006).Conclusion The RSFC in the mesolimbic system and the VTA-DMN circuit exist abnormal changes in smokers.To some extent,it may explain the reward deficits and dysfunction of emotion regulation in smokers,which may provide clues for further understanding the mechanism of tobacco addict

关 键 词：物质依赖 烟草 功能连接 腹侧被盖区 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.6[医药卫生—诊断学]