人免疫缺陷病毒广谱中和抗体的研究进展  

Research progress of broadly neutralizing antibodies against human immunodeficiency virus

作　　者：张慧 邓婷婷(综述) 李少伟[1,2] 顾颖(审校)[1,2] ZHANG Hui;DENG Ting-ting;LI Shao-wei;GU Ying(不详;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,Fujian Province,China)

机构地区：[1]厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室,福建厦门361102 [2]厦门大学生命科学学院国家传染病诊断试剂与疫苗工程技术研究中心,福建厦门361102

出　　处：《中国生物制品学杂志》2023年第2期217-223,234,共8页Chinese Journal of Biologicals

基　　金：国家自然科学基金(82171821)。

摘　　要：艾滋病(acquired immune deficiency syndrome,AIDS)是全球性公共卫生问题,对人类生命健康造成了重大影响。人免疫缺陷病毒1型(human immunodeficiency virus type-1,HIV-1)是AIDS的主要致病原,具有高变异性和潜伏性,因此缺乏有效的疫苗和药物进行AIDS的预防及治疗。HIV-1广谱中和抗体(broadly neutralizing antibodies,bNAbs)在机体内可针对HIV-1感染产生有效的免疫应答,可同时中和不同型别毒株,在预防HIV-1感染及控制AIDS进程中具有巨大应用潜力。本文就HIV-1 bNAbs的产生及获得、分类及特点、应用情况作一综述,以期为后续HIV-1疫苗研究和抗体药物开发提供参考。Acquired immune deficiency syndrome(AIDS)is a global public health issue,which has a major impact on human life and health.As the main pathogen of AIDS,human immunodeficiency virus type 1(HIV-1)has high variability and latent characteristics,there are no available vaccines and drugs to prevent and cure AIDS.The broadly neutralizing antibodies(bNAbs)against HIV-1 can induce effective immune response to HIV-1 infection in vivo,and neutralize different types of strains at the same time,which have great application potential in preventing HIV-1 infection and controlling the process of AIDS.In this paper,the production and acquisition,classification and characteristics as well as application of HIV-1bNAbs are reviewed so as to provide a reference for the subsequent research on HIV-1 vaccine and development of antibody drugs.

关 键 词：人免疫缺陷病毒 广谱中和抗体 艾滋病 

分 类 号：R512.91[医药卫生—内科学]