武汉市社区居民对粪菌移植的认知、态度及意愿的调查  

Investigation on cognition,attitude and willingness toward fecal microbiota transplantation among community residents in Wuhan City

作　　者：陈梦[1] 王念[1] 马红梅[1] 方婷 赵雪娇 冯鸿 CHEN Meng;WANG Nian;MA Hong-mei;FANG Ting;ZHAO Xue-jiao;FENG Hong(Department of Geriatrics,People's Hospital of Wuhan University,Wuhan Hubei,430060,China)

机构地区：[1]武汉大学人民医院老年病科,湖北武汉430060

出　　处：《职业与健康》2023年第2期216-220,共5页Occupation and Health

基　　金：国家自然科学基金青年项目(82100249)。

摘　　要：目的 了解武汉市社区居民对粪菌移植(fecal microbiota transplantation,FMT)的认知、态度及粪便捐献意愿的情况,为该技术的普及和应用提供参考依据。方法 2021年8月,采取方便取样法,抽取武汉市6大社区582名居民为调查对象,采用自行设计的问卷进行调查,并对结果进行统计分析。结果 社区居民对FMT的认知得分为(0.26±0.44)分,对FMT的接受度为44.16%,不同性别、学历、消化道疾病就医史的居民接受FMT治疗的态度差异均有统计学意义(均P<0.05)。Logistic回归分析显示,女性、大专及以上学历者和接受FMT者的粪便捐献意愿更高(OR=3.18、2.36、6.58,95%CI=1.73~5.84、1.35~4.15、3.30~13.13,均P<0.05)。除医师推荐外,将粪菌制成胶囊口服是大众最接受的移植途径(32.09%),居民最愿意选择亲属作为供体来源(29.03%);79.55%的居民愿意捐献自身粪便,不同性别、学历、职业和FMT接受度的人群的粪便捐献意愿差异均有统计学意义(均P<0.05)。结论 社区居民对FMT的认知程度较低,对FMT治疗接受度处于中等水平,但绝大多数居民的粪便捐献意愿较高。今后,需加大FMT的推广力度,使更多人认识到FMT治疗疾病的临床价值。Objective To understand the cognition and acceptance of fecal microbiota transplantation(FMT),fecal donation intention of community residents in Wuhan City,provide reference for the popularization and application of the technology.Methods In August 2021,totally 582 residents from six major communities in Wuhan were selected as survey subjects by the convenient sampling method,the survey was conducted using self-designed questionnaires,and the results were statistically analyzed.Results The score of cognition o FMT in community residents was(0.26±0.44)points,and the acceptance rate of FMT was44.16%.There were statistically significant differences in the attitude to FMT treatment among community residents with different gender,educational background and medical history of gastrointestinal diseases(all P<0.05).The logistic regression analysis showed that women,college degree or above and those who received FMT had higher willingness to donate feces(OR=3.18,2.36,6.58,95% CI =1.73-5.84,1.35-4.15,3.30-13.13,all P <0.05).In addition to the doctor’s recommendation,taking fecal bacteria into capsules orally was the most accepted transplant route(32.09%).Residents were most willing to choose relatives as the source of donors(29.03%).79.55% of community residents were willing to donate their own feces.There were statistically significant differences in the fecal donation willingness among residents with different gender,education,occupation and FMT acceptance(all P<0.05).Conclusions Most community residents have a low awareness of FMT,and their acceptance of FMT treatment is at a moderate level.However,the majority of community residents have a high willingness to donate feces.In the future,the promotion of FMT should be strengthened to make more people realize the clinical value of FMT.

关 键 词：粪菌移植 认知 态度 捐献意愿 

分 类 号：R181.39[医药卫生—流行病学]