Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity  

作　　者：Xing Wang Ya-Qiang Wang De-Cheng Wu 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Polymer Physics&Chemistry,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China

出　　处：《Chinese Journal of Polymer Science》2023年第4期564-573,I0008,共11页高分子科学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.51973226,21935011 and 81871782);the Youth Innovation Promotion Association CAS(No.2019031).

摘　　要：In the current global crisis of antibiotic resistance,persuit of an effective multi-pathway collaborative approach to enhance antibacterial activity is urgently needed.Here,a kind of hyperbranched polyacetal quaternary ammonium(Hyper-ace-QA)with efficiently antibacterial function were synthesized by a succession of efficient click strategies.The high molecular weights can be obtained just after UV irradiation for 3 h,and the grafting ratio can be easily adjusted through controlling solvent system,molar ratio,and temperature.Cytotoxicity studies indicated that Hyper-ace-QA had good biocompatibility and can be used as a potential antibacterial dressing.More importantly,after in situ encapsulation of bioactive curcumin drugs into the hyperbranched intramolecular cavities,the acid-liable acetal linkers within the hyperbranched backbone made the loading antibacterial drugs rapidly release with pH-or bacterial-responsive behaviors since many bacteria can produce acids at the infection site by the combined actions of immune response and bacterial metabolism.Therefore,the integration of quaternary ammonium characteristics and pH-triggered curcumin release could facilitate the antibacterial activity against gram-positive Staphylococcus aureus.This work represents a synergistic strategy on offering important guidance to rational design of multifunctional antimicrobial vehicles,which would be promising therapeutic alternatives for first aid treatment of wound infection in critical situations.

关 键 词：Hyperbranched polymer ACETAL Quaternary ammonium PH-RESPONSIVE Antibacterial activity 

分 类 号：O63[理学—高分子化学]