光声成像技术在生物医学中的研究进展(特邀)  

Recent Advances of Photoacoustic Imaging Technology in Biomedicine(Invited)

作　　者：申晓雯 武红鹏[1] 董磊[1] SHEN Xiaowen;WU Hongpeng;DONG Lei(State Key Laboratory of Quantum Optics and Quantum Optics Devices,Institute of Laser Spectroscopy,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学激光光谱研究所,量子光学与光量子器件国家重点实验室,太原030006

出　　处：《光子学报》2023年第3期73-91,共19页Acta Photonica Sinica

基　　金：国家重点研究发展计划(No.2019YFE0118200);国家自然科学基金(Nos.62235010,62175137,62122045,62075119);山西省杰出青年基金(No.20210302121003)。

摘　　要：随着光声光谱的不断发展,以光声效应为基础所兴起的非侵入式光声成像技术正逐步成为生物医学的研究热点。该技术除具有光学成像优点外,还拥有声学深度传播优势,能够突破光学衍射极限、散射极限,获得高成像分辨率。本文介绍了光声成像的原理机制,对目前三种典型光声成像技术:光声断层成像技术、光声显微镜技术和光声内窥镜技术分别进行了介绍,总结对比了这三种成像技术的优势,同时总结了近十几年随着光声技术的不断发展,为提高其成像分辨率的各类方法,最后展望了三种技术的未来发展趋势。With the development of photoacoustic spectroscopy,non-invasive photoacoustic imaging technology based on the photoacoustic effect is gradually becoming a research hotspot in biomedical applications.This technology combines the benefits of optical imaging with the advantages of acoustic depth propagation,allowing it to break through the optical diffraction limit and scattering limit while maintaining a high imaging resolution.This article first introduces the principal mechanism of photoacoustic imaging and then introduces the three typical photoacoustic imaging technologies:photoacoustic computed tomography,photoacoustic microscopy and photoacoustic endoscopy.Furthermore,the benefits of these three imaging technologies are compared,and the various methods to improve imaging resolution over the last ten years are summarized.Finally,the future development trend of the three technologies is forecasted.Photoacoustic tomography was the first photoacoustic imaging technique to be developed.Traditional medical tomography plays an important role in diagnosing diseases,but that is not completely safe due to the presence of radiation that can cause some damage to the human body.Photoacoustic tomography is one of the safe imaging methods based on the photoacoustic effect that is radiation-free.Since the 1990 s,photoacoustic computed tomography has made significant progress.Researchers have improved the imaging resolution and imaging reconstruction speed of photoacoustic computed tomography by increasing the number of ultrasound transducers and improving the accuracy of the algorithm.This technology has achieved many excellent results in human breast cancer detection.The advantage of photoacoustic microscopy is that it has a higher imaging resolution at the same penetration depth than the photoacoustic computed tomography system.The photoacoustic signals of photoacoustic microscopy systems are generated at the point where the light and acoustic focal points overlap,so,photoacoustic microscopy systems are usually divided int

关 键 词：光声光谱 生物医学 光声成像 结构成像 

分 类 号：Q631[生物学—生物物理学]