Associations between maternal vitamin D status and porcine litter characteristics throughout gestation  

作　　者：Claire Stenhouse Emma Hurst Richard J.Mellanby Cheryl J.Ashworth 

机构地区：[1]Functional Genetics and Development Division,The Roslin Institute and Royal(Dick)School of Veterinary Studies,University of Edinburgh,Midlothian EH259RG,UK [2]Current Affiliation,Department of Animal Science,Texas A&M University,College Station,Texas 77843‑2471,USA [3]Clinical Sciences Division,The Roslin Institute and Royal(Dick)School of Veterinary Studies,University of Edinburgh,Midlothian EH259RG,UK.

出　　处：《Journal of Animal Science and Biotechnology》2023年第2期806-813,共8页畜牧与生物技术杂志（英文版）

基　　金：The Roslin Institute receives Institute Strategic Grant funding from the BBSRC(BB/J004316/1).

摘　　要：Emerging evidence suggests an important role of vitamin D in the establishment and maintenance of pregnancy,and the regulation of foetal growth across mammalian species.However,the temporal changes in maternal vitamin D sta-tus throughout gestation in the pig and the relationship between maternal vitamin D status and litter characteristics of interest across gestation remain poorly understood and under-investigated.The abundance of 25(OH)D in maternal plasma was quantified by HPLC–MS/MS at gestational days(GD)18,30,45,60 and 90(n=5–11 gilts/GD).Maternal plasma 25(OH)D concentrations significantly increased between GD18 and GD30(P<0.05).The relationship between maternal vitamin D metabolite concentrations and litter characteristics of interest including gilt weight,ovulation rate,mean litter weight,number of live foetuses,percentage prenatal survival,and sex ratio of the litter was assessed.Maternal 25(OH)D(P=0.059)concentrations tended to be positively associated with percentage prenatal survival on GD60.On GD90,maternal 25(OH)D(P<0.05)concentrations were inversely associated with gilt weight.Maternal plasma 25(OH)D concentrations were inversely associated with the percentage of male foetuses in the litter on GD90(P<0.05).This study has provided novel insights into temporal changes in maternal vitamin D status throughout ges-tation and the relationship between maternal vitamin D status and the economically important litter characteristics of gilt weight,percentage prenatal survival and percentage of male foetuses in the litter.Improving the understanding of the role of vitamin D across important developmental timepoints in relation to foetal growth is essential to improve reproductive success in livestock species.

关 键 词：PORCINE PREGNANCY Vitamin D 

分 类 号：S858[农业科学—临床兽医学]