急性创伤后早期脑功能网络的静息态功能磁共振成像研究  

Early brain functional networks after acute stress:A resting-state fMRI study

作　　者：赵纳[1] 孟令惠[1] 杜国帅 张英东[2] 刘红冉 高明龙[2] 任贝贝 刘富荣 张力 ZHAO Na;MENG Linghui;DU Guoshuai;ZHANG Yingdong;LIU Hongran;GAO Minglong;REN Beibei;LIU Furong;ZHANG Li(Department of CT/MRI,the Third Hospital of Hebei Medical University,Shijiazhuang 050000,China;Mental Health Center,the First Hospital of Medical University,Shijiazhuang 050000,China;Department of CT/MRI,Neiqiu Traditional Chinese Medicine Hospital,Xingtai 054200,China;Department of Radiology and Nuclear Medicine,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第三医院CT/MRI室,石家庄050000 [2]河北医科大学第一医院精神卫生中心,石家庄050000 [3]河北省内丘县中医院CT/MRI室,邢台054200 [4]河北医科大学第一医院放射与核医学科,石家庄050000

出　　处：《磁共振成像》2023年第3期48-52,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：河北省自然科学基金(编号:H2020206278);河北省省级科技计划(编号:20377734D)。

摘　　要：目的基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)采用图论方法探讨急性创伤后早期脑功能网络拓扑属性的变化。材料与方法创伤组纳入河北医科大学第三医院2020年11月至2022年4月门诊及住院的36例交通事故受害者,同期对照组纳入43例年龄、性别、受教育程度与创伤组相匹配的健康者,创伤组的数据采集在经历交通事故后1周内进行,2组受试者均进行临床数据和MRI数据采集。使用GRETNA(Graph Theoretical Network Analysis)软件构建所有受试者的脑功能网络,获得脑网络指标值,包括全局水平指标[聚类系数(clustering coefficient,Cp)、标准聚类系数γ、最短路径长度(shortest path length,Lp)、标准最短路径长度λ、小世界性σ、全局效率(global efficiency,Eg)和局部效率(local efficiency,Eloc)]以及节点水平指标。比较两组间脑网络指标的差异,节点水平指标的分析结果进行多重比较(false discovery rate,FDR)校正。创伤组脑网络指标与焦虑评分进行相关性分析。结果创伤组与对照组脑功能网络均具有小世界属性。全局水平指标中两组间Lp和Eg的差异均具有统计学意义,P值均<0.05(分别为0.001、0.015);Cp、γ、λ、σ和Eloc的差异均无统计学意义(分别为0.390、0.127、0.192、0.115、0.129,P>0.05)。节点水平指标中两组间双侧枕下回节点中心性的差异均具有统计学意义(左,P=0.020;右,P=0.040;P<0.05,FDR校正)。创伤组脑网络指标未见与焦虑评分相关(P>0.05)。结论急性创伤后早期脑功能网络仍然具有小世界属性,但其整体的信息传输能力下降,节点中心性也发生了改变。Objective:To investigate the alterations of functional brain network topology shortly after acute stress using resting-state functional magnetic resonance imaging(rs-fMRI)with graph theory method.Materials and Methods:Trauma group involved 36 motor vehicle accidents(MVA)survivors at the Third Hospital of Hebei Medical University between November 2020 and April 2022,and control group recruited 43 gender-,age-and education degree-matched healthy subjects.All subjects got MRI scan and clinical evaluation.MVA survivors received MRI scan and trauma-specific clinical assessments within 1 week from the MVA.Based rs-fMRI with GRETNA(Graph Theoretical Network Analysis)toolbox,Topologic properties of brain functional network were investigated at both global and nodal level.The global level properties included clustering coefficient(Cp);shortest path length(Lp);normalized Cpγ;normalized Lpλ;small-worldnessσ,local efficiency(Eloc)and global efficiency(Eg).Group differences in those properties were explored.In MVA group,correlation analyses were peformed to detect the relationship between topologic properties and anxiety scores.Results:The functional brain network fitted the definition of small⁃worldness in MVA survivors and controls.Significantly higher Lp(P=0.001,P<0.05)and lower Eg(P=0.015,P<0.05)values were found in MVA survivors as compared with those in control group.There were no statistically significant group differences in Cp、γ、λ、σand Eloc(P>0.05).MVA survivors showed increased nodal centralities in bilateral inferior occipital gyrus(Left,P=0.020;Right,P=0.040;P<0.05,FDR correction).There was no significant relationship between topologic properties and anxiety scores.Conclusions:These results indicate the functional brain network of MVA survivors exhibit small⁃worldness,but altered global and nodal topological properties shortly after acute stress.

关 键 词：急性创伤 脑功能 脑网络 图论 静息态功能磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.12[医药卫生—诊断学]