黏液脓性宫颈炎阴道分泌物主要病原菌构成及其对抗菌药物的耐药性  

Main Pathogenic Bacteria in Vaginal Secretions of Mucopurulent Cervicitis and Their Resistance to Antibiotics

作　　者：李盼盼[1] 朱涛[1] 高攀攀 LI Panpan;ZHU Tao;GAO Panpan(Department of Laboratory Medicine,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Clinical Nutritionthe,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第五附属医院检验科,河南郑州450000 [2]郑州大学第五附属医院临床营养科,河南郑州450000

出　　处：《河南医学研究》2023年第4期645-648,共4页Henan Medical Research

摘　　要：目的 探究黏液脓性宫颈炎(MPC)阴道分泌物病原菌构成特点,并依照药敏试验结果观察抗菌药物使用情况。方法 选取2019年5月至2022年2月郑州大学第五附属医院317例MPC患者作为研究组,按照1∶1配对原则,纳入健康体检妇女317例作为对照组。统计两组阴道分泌物病原菌培养和药敏试验结果,分析其检出病原菌分布情况及对不同抗菌药物耐药性。结果 MPC患者细菌阳性、支原体属阳性检出率高于健康人群(P<0.05);MPC患者革兰阳性菌感染率(64.29%)高于革兰阴性菌感染率(35.71%)(P<0.05);淋病奈瑟球菌对环丙沙星、四环素耐药严重,大肠埃希菌对氨苄西林、四环素、阿莫西林、氯霉素耐药严重,肺炎克雷伯球菌对氨苄西林、环丙沙星、左氧氟沙星耐药严重,但淋病奈瑟球菌、大肠埃希菌、肺炎克雷伯球菌均对美罗培南耐药性为0;粪肠球菌对四环素、阿莫西林耐药严重,无乳链球菌对阿莫西林、环丙沙星耐药严重,金黄色葡萄球菌对红霉素、阿莫西林、环丙沙星耐药严重,但粪肠球菌、无乳链球菌、金黄色葡萄球菌均对万古霉素耐药性为0。结论 MPC患者阴道分泌物感染病原菌以革兰阳性菌为主,且其耐药率表现不一,建议临床结合阴道分泌物实施菌株鉴定,并结合药敏试验结果,合理用药,从而确保治疗效果。Objective To explore the characteristics of pathogenic bacteria in vaginal secretions of mucopurulent cervicitis(MPC), and to observe the use of antibiotics according to the results of drug susceptibility tests.Methods A total of 317 MPC patients in the Fifth Affiliated Hospital of Zhengzhou University from May 2019 to February 2022 were selected as the research group, and 317 healthy women were included as the control group according to the 1∶1 matching principle. The results of bacterial culture and drug susceptibility testing of vaginal secretions in the two groups were counted, and the distribution of detected pathogens and their resistance to different antibiotics were analyzed.Results The positive rate of bacteria and mycoplasma in MPC patients was higher than that in healthy people(P<0.05). The infection rate of gram-positive bacteria in MPC patients was 64.29%, which was higher than that of gram-negative bacteria(35.71%)(P<0.05). Neisseria gonorrhoeae was severely resistant to ciprofloxacin and tetracycline, Escherichia coli was severely resistant to ampicillin, tetracycline, amoxicillin and chloramphenicol, and Klebsiella pneumoniae was resistant to ampicillin and ciprofloxacin, levofloxacin, but Neisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae resistance to meropenem was 0. Enterococcus faecalis was severely resistant to tetracycline and amoxicillin, Streptococcus agalactiae was severely resistant to amoxicillin and ciprofloxacin, and Staphylococcus aureus was severely resistant to erythromycin, amoxicillin and ciprofloxacin, but Enterococcus faecalis, Streptococcus agalactiae, Staphylococcus aureus resistance to vancomycin was 0.Conclusion The pathogens of vaginal secretion infection of MPC patients are mainly gram-positive bacteria, and their drug resistance rates are different. It is recommended to carry out bacterial strain identification in combination with vaginal secretions, and combine the results of drug susceptibility test to rationally use drugs, so as to ensure the therapeuti

关 键 词：宫颈炎 病原菌 耐药性 阴道分泌物 

分 类 号：R446.1[医药卫生—诊断学]