阿罗洛尔辅助缬沙坦氢氯噻嗪治疗老年顽固性高血压患者的效果  

Effects of Arolol Combined with Valsartan Hydrochlorothiazide on Elderly Patients with Intractable Hypertension

作　　者：马琳 张宁 王浩坤 MA Lin;ZHANG Ning;WANG Haokun(Department of Cardiovascular Medicine,the First People’s Hospital of Xinmi,Zhengzhou 452370,China;Department of Cardiology,Zhengzhou People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]新密市第一人民医院心血管内科,河南郑州452370 [2]郑州市人民医院心内科,河南郑州450000

出　　处：《河南医学研究》2023年第4期723-726,共4页Henan Medical Research

摘　　要：目的 探讨阿罗洛尔辅助缬沙坦氢氯噻嗪联合治疗老年顽固性高血压患者的效果。方法 选取新密市第一人民医院2018年7月至2019年10月收治的94例顽固性高血压患者。根据采用的药物治疗方案分为单药治疗组和联合药物治疗组,各47例。单药治疗组接受缬沙坦氢氯噻嗪单药治疗,联合药物治疗组接受阿罗洛尔辅助缬沙坦氢氯噻嗪进行联合治疗。比较两组的疗效、治疗前后收缩压(SBP)、舒张压(DBP)、心率(HR)水平以及生化指标[血糖、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]水平、不良反应发生率。结果 联合药物治疗组总有效率为93.62%,高于单药治疗组(74.47%)(P<0.05);治疗1个月后,两组SBP、DBP、HR水平均低于治疗前,组内治疗前后对比,差异有统计学意义(P<0.05);且治疗1个月后,联合药物治疗组SBP、DBP、HR水平低于单药治疗组(P<0.05);治疗前后两组血糖、TG、LDL-C水平及不良反应发生率比较差异无统计学意义(P>0.05)。结论 顽固性高血压患者接受阿罗洛尔联合缬沙坦氢氯噻嗪治疗效果显著,能有效降低血压水平,并在一定程度上控制心率,对患者糖脂代谢无影响,较为安全。Objective To analyze the effects of arolol combined with valsartan hydrochlorothiazide on elderly patients with intractable hypertension.Methods From July 2018 to October 2019, 94 patients with refractory hypertension in the First People’s Hospital of Xinmi were selected and divided into two single drug treatment group and combined drug treatment group according to different drug treatment schemes, with 47 patients in each group. Patients in the single drug treatment group received valsartan hydrochlorothiazide treatment, patients in the combined drug treatment group received arolol combined with valsartan hydrochlorothiazide treatment. Curative effect, systolic blood pressure(SBP), diastolic pressure(DBP), heart rate(HR), biochemical indexes [blood glucose, triglyceride(TG), low density lipoprotein cholesterol(LDL-C)] before and after one month of treatment, the incidence of adverse reactions were compared between single drug treatment group and combined drug treatment group.Results The total effective rate of the combined drug treatment group was 93.62%, which was higher than that of the single drug treatment group(74.47%)(P<0.05). After one month of treatment, the SBP, DBP and HR in both groups were lower than before treatment(P<0.05), and the SBP, DBP and HR in the combined drug treatment group were lower than those in the single drug treatment group after one month of treatment(P<0.05). There were no significant differences in the levels of blood glucose, TG, LDL-C before and after one month of treatment and the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of refractory hypertension with arolol combined with valsartan hydrochlorothiazide has a significant effect, which can reduce the blood pressure and control the heart rate to a certain extent. It has no effect on the glucose and lipid metabolism of patients and is relatively safe.

关 键 词：顽固性高血压 阿罗洛尔 缬沙坦氢氯噻嗪 收缩压 舒张压 糖脂代谢 

分 类 号：R544.1[医药卫生—心血管疾病]