从“心合小肠”探讨TGF-β/Smads信号通路与慢性心衰肠道微生态的相关性  

Correlation of TGF-β/Smads signaling pathways with intestinal microecological imbalance of chronic heart failure based on "the paring between the heart and small intestine" in Chinese medicine

作　　者：罗佳敏 肖清玄 陈宇霞 陈杏 朱洁 张书萌 陈伶利[1] 李杰[1] LUO Jiamin;XIAO Qingxuan;CHEN Yuxia;CHEN Xing;ZHU Jie;ZHANG Shumeng;CHEN Lingli;LI Jie(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2023年第3期400-404,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(81874375);湖南省自然科学基金项目(2020JJ4464);湖南省中医药科研计划重点项目(2021024);湖南省教育厅科研计划重点项目(17A163);湖南中医药大学校级科研重点项目(2020XJJJ002)。

摘　　要：慢性心力衰竭作为多种心血管疾病发展到终末期的疾病阶段,已成为当今全球高发病率和病死率的主要原因之一。肠道菌群与慢性心力衰竭的发生发展关系密切,转化生长因子-β(transforming growth factor-β, TGF-β)/Smads信号通路和/或肠道菌微生态失衡能诱导心肌纤维化,促进慢性心力衰竭的发生发展。本文从中医“心合小肠”理论出发,以TGF-β/Smads信号通路调控慢性心力衰竭为主线,探讨肠道微生态失衡在其中的作用机制,以期为慢性心力衰竭的治疗研究提供新思路和参考。As the final stage in the development of various cardiovascular diseases, chronic heart failure has become one of the main causes of high morbidity and mortality worldwide. The transforming growth factor-β(TGF-β)/Smads signaling pathways and/or the intestinal microecological imbalance can induce myocardial fibrosis and promote the occurrence and development of chronic heart failure, so the condition of the intestinal flora is closely related to this disease. Therefore, based on the TCM theory of "the paring between the heart and small intestine", this paper has taken the regulation of TGF-β/Smads signaling pathways on chronic heart failure as the main line to explore the influence of the intestinal microecological imbalance on it and its mechanism,in order to provide new thoughts and reference for its treatment.

关 键 词：慢性心力衰竭 转化生长因子-Β SMADS蛋白 肠道微生态 心合小肠 

分 类 号：R259[医药卫生—中西医结合]