甲状腺激素与糖尿病慢性并发症患病率的相关性分析  

Analysis of correlation between thyroid hormone and prevalence of chronic complications in diabetes mellitus

作　　者：陈谱[1] 强薇[1] 赵曼 王荣[1,2] CHEN Pu;QIANG Wei;ZHAO Man;WANG Rong(Department of Endocrinology,The First Affiliated Hospital of Xi′an Jiaotong University,Xi′an Shanxi 710061;Department of Endocrinology,The First Hospital of Yulin,Yulin Shanxi 719000;Department of Laboratory,Xi′an NO.1 Hospital,Xi′an Shanxi 710002,China)

机构地区：[1]西安交通大学第一附属医院内分泌科,陕西西安710061 [2]陕西省榆林市第一医院内分泌科,719000 [3]陕西省西安市第一医院检验科,710002

出　　处：《蚌埠医学院学报》2023年第3期323-326,共4页Journal of Bengbu Medical College

基　　金：国家自然科学基金青年基金项目(81802829);陕西省自然基础研究项目(2020JQ-501);西安交通大学第一附属医院课题项目(2018MS-01)。

摘　　要：目的:探讨正常范围内甲状腺激素水平与2型糖尿病(T2DM)病人下肢血管病变(LEAD)及周围神经病变(DPN)患病率的相关性。方法:收集初诊的1342例T2DM病人临床资料,根据病人疾病诊断结果分为单纯T2DM组348例、LEAD组704例和DPN组290例,比较3组病人的临床及代谢指标,并分析不同水平甲状腺激素病人LEAD及DPN的患病率及其相关性。结果:年龄、游离甲状腺素(FT4)、总蛋白、白蛋白、载脂蛋白E在3组间差异均有统计学意义(P<0.05~P<0.01)。按甲状腺激素的四分位数进行分层,分析发现不同FT4水平病人的LEAD和DPN患病率间差异有统计学意义(P<0.05)。多因素logistic回归分析显示,FT4为LEAD和DPN发生的独立影响因素(P<0.05~P<0.01)。结论:低水平的FT4为T2DM病人发生LEAD和DPN的风险因素。Objective:To identify the correlation between normal thyroid hormones and the prevalence of lower-extremity arterial disease(LEAD)and diabetes peripheral neuropathy(DPN)in type 2 diabetes mellitus(T2DM)patients.Methods:A total of 1342 T2DM patients were enrolled from January 2014 to October 2020 at the First Affiliated Hospital of Xi′an Jiaotong University and stratified into T2DM group(348 cases),LEAD group(704 cases)and DPN group(290 cases)depending on their disease′s diagnosis.The differences in basic data and biochemical indexes between the three groups were compared.At the same time,the correlation between the incidence of LEAD,DPN and thyroid hormone was analyzed.Results:Age,free thyroxine(FT4),total protein(TP),albumin(ALB),apolipoprotein E(apo E)were significantly different among the three groups(P<0.05 to P<0.01).Stratified by the quartile of thyroid hormone,it was found that there were statistically significant differences in the prevalence of LEAD and DPN among patients with different FT4 levels(P<0.05).Multivariate logistic regression analysis showed that FT4 was an independent factor affecting the occurrence of lead and DPN(P<0.05 to P<0.01).Conclusions:Low level of FT4 is a risk factor for LEAD and DPN in patients with T2DN.

关 键 词：2型糖尿病 糖尿病下肢血管病变 糖尿病周围神经病变 甲状腺激素 

分 类 号：R587.1[医药卫生—内分泌]