中医药联合HAART治疗艾滋病对CD4+T淋巴细胞数量影响的临床研究  被引量:2

Clinical study on the influence of traditional Chinese medicine combined with HAART on CD4+T lymphocyte count in the treatment of AIDS

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作  者:田原 孔德娣 张帼峻 杨雯涵 戴颖 Tian Yuan;Kong Dedi;Zhang Guojun;Yang Wenhan;Dai Ying(The seventh hospital of Qiqihar,Qiqihar,Heilongjiang,161006,China)

机构地区:[1]齐齐哈尔市第七医院,黑龙江齐齐哈尔161006

出  处:《齐齐哈尔医学院学报》2023年第3期231-234,共4页Journal of Qiqihar Medical University

基  金:齐齐哈尔市科学技术局项目(CSFGG-2021010)。

摘  要:目的观察中医药方剂(免疫Ⅰ号)联合高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)治疗艾滋病疗效。方法选择2019年1月—2022年6月本院收治的100例符合入组标准的艾滋病感染者及患者作为研究对象,随机数表法分为观察组和对照组两组,每组各50例。对照组单纯采用HAART治疗(TDF+3TC+EFV,既替诺福韦300 mg+拉米夫定300 mg+依非韦伦400 mg,每日一次),观察组在对照组的基础上给予免疫Ⅰ号方剂,早晚服用。两组治疗30 d为1个疗程,均治疗6个疗程。观察治疗前后采用流式细胞计数测定CD4+计数,以及用药后对不良反应症状的影响,采用RT-PCR检测病毒载量。结果治疗组皮肤瘙痒、失眠、头痛等治疗效果明显优于对照组,差异有统计学意义(均P<0.05)。治疗组和对照组治疗后CD4+绝对计数较治疗前升高,差异有统计学意义(均P<0.05);治疗组治疗后CD4+绝对计数高于对照组,差异有统计学意义(P<0.05)。治疗组治疗后病毒载量较治疗前降低,差异有统计学意义(P<0.05);对照组治疗前后病毒载量差异无统计学意义(P>0.05)。结论中医药方剂(免疫Ⅰ号)联合高效抗逆转录病毒治疗可改善艾滋病感染者、患者的临床症状,有效提升CD4+T淋巴细胞数量,对重建免疫功能、提高患者的生存质量及延长生存期,具有积极的临床作用及意义,可在临床积极推广。Objective To observe the curative effects of traditional Chinese medicine(Immune I)combined with highly active antiretroviral therapy(HAART)in the treatment of AIDS.Methods 100 patients with HIV/AIDS who were admitted to our hospital from January 2019 to June 2022 were selected as observation objects,and they were randomly divided into observation group and control group,with 50 cases in each group.The patients in control group were treated with HAART alone(TDF+3TC+EFV,tenofovir 300 mg and lamivudine 300 mg and efavirenz 400 mg,once a day),and the patients in observation group were given immune I prescription on the basis of the control group,administrated at morning and evening.The two groups were treated for 30 days as a course,and totally 6 courses.The CD4+count was measured by flow cytometry before and after treatment,and the effect of medication on the symptoms of adverse reactions was observed.The viral load was detected by RT-PCR.Results The therapeutic effect of pruritus,insomnia and headache in the treatment group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).The absolute CD4+count in the treatment group and the control group after treatmentwere higher than those before treatment,and the differences were statistically significant(P<0.05).The absolute CD4+count in the treatment group was higher than that in the control group after treatment,and the difference was statistically significant(P<0.05).The viral load of the treatment group was lower after treatment than that before treatment,the difference was statistically significant(P<0.05).There was no significant difference in viral load before and after treatment in control group(P>0.05).Conclusions Traditional Chinese medicine prescription(Immune-I)combined with highly effective antiretroviral therapy could improve the clinical symptoms of HIV infected patients orAIDS patients,effectively increases the number of CD4+T lymphocytes.It is of positive clinical efficacy and significance fo

关 键 词:艾滋病 高效抗反转录病毒治疗 中医药 

分 类 号:R259[医药卫生—中西医结合]

 

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