不同剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期排卵障碍性异常子宫出血的临床疗效  

Clinical effect of different doses of mifepristone combined with deoxygestrel estradiol in the treatment of perimenopausal uterine bleeding with abnormal ovulation disorder

作　　者：张小月[1] Zhang Xiaoyue(Department of Obstetrics and Gynecology,Dongtai Hospital of Traditional Chinese Medicine,Dongtai 224200,China)

机构地区：[1]东台市中医院妇产科,江苏东台224200

出　　处：《实用妇科内分泌电子杂志》2022年第29期53-55,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨不同剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期排卵障碍性异常子宫出血的临床疗效。方法选取76例围绝经期排卵障碍性异常子宫出血患者,根据随机数字表法分为小剂量组与大剂量组,每组38例。小剂量组予以米非司酮10 mg+去氧孕烯炔雌醇治疗,大剂量组予以米非司酮25 mg+去氧孕烯炔雌醇治疗。比较两组临床效果及安全性。结果两组患者临床总有效率比较差异无统计学意义(P>0.05)。治疗前,两组血清卵泡刺激素(FSH)、促黄体生成素(LH)及孕酮(P)水平比较,差异无统计学意义(P>0.05);治疗后,两组性激素水平均较治疗前改善,但治疗后组间FSH、LH及P水平比较差异无统计学意义(P>0.05)。小剂量组药物不良反应总发生率7.89%低于大剂量组的26.32%,差异有统计学意义(P<0.05)。结论不同剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期排卵障碍性异常子宫出血的临床效果无明显差异,但小剂量米非司酮药物安全性更高。Objective To investigate the clinical effect of different doses of Mifepristone combined with deoxypregnenedyneestradiol in the treatment of perimenopausal abnormal uterine bleeding with ovulation disorder.Methods 76 perimenopausal patients with abnormal uterine bleeding due to ovulation disorder were selected and divided into low-dose group and high-dose group according to random number table method,with 38 cases in each group.The low-dose group was treated with mifepristone 10 mg+deoxypregnenethinylestradiol,and the high-dose group was treated with Mifepristone 25 mg+deoxypregnenethinylestradiol.The clinical effect and safety of the two groups were compared.Results There was no signifi cant difference in total clinical effective rate between the two groups(P>0.05).Before treatment,there were no significant differences in serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and progesterone(P)between 2 groups(P>0.05).After treatment,sex hormone levels in both groups were improved compared with those before treatment,but there was no significant difference in FSH,LH and P levels between groups after treatment(P>0.05).The total incidence of ADR in low-dose group was 7.89%lower than that in high-dose group 26.32%,and the difference was statistically signifi cant(P<0.05).Conclusion Different doses of mifepristone combined with deoxygestrel estradiol in the treatment of perimenopausal uterine bleeding with abnormal ovulation disorder have no significant difference in clinical efficacy,but small doses of mifepristone is safer.

关 键 词：围绝经期排卵障碍性异常子宫出血 小剂量米非司酮 大剂量米非司酮 去氧孕烯炔雌醇 临床疗效 

分 类 号：R711[医药卫生—妇产科学]