依托考昔对急性痛风性关节炎患者关节病变及肝肾功能改善效果  

Effects of Joint Lesion and Liver-kidney Function in Acute Gouty Arthritis Patients with Etoricoxib

作　　者：黎志锋[1] 陈国强[1] 张红卫[1] 罗绮雯[1] LI Zhi-feng;CHEN Guo-qiang;ZHANG Hong-wei(The first people's hospital of Foshan,Foshan,Guangdong 528000)

机构地区：[1]佛山市第一人民医院,广东佛山528000

出　　处：《中国伤残医学》2023年第1期21-24,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:研究依托考昔对急性痛风性关节炎患者的关节病变和肝肾功能的影响。方法:选择我院2016年6月-2017年6月诊治的急性痛风性关节炎患者120例,随机分为对照组和观察组,各60例。对照组采用双氯芬酸钠75mg/d口服,观察组采用依托考昔60mg/d口服,必要时联合关节腔内注射皮质类固醇(复方倍他米松3.5mg+2%利多卡因0.5ml+生理盐水0.5ml),疗程为5天。比较治疗前和治疗后1天、3天、5天关节病变评分(包括疼痛、触痛、肿胀和皮肤红晕4项),血尿酸、血沉、C反应蛋白(CRP)和白细胞计数,肝功能(ALT水平),肾功能(血肌酐水平)以及不良反应。结果:治疗后观察组与对照组关节病变评分均逐渐降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后5天观察组血尿酸、血沉、CRP水平和白细胞计数均明显低于对照组,差异有统计学意义(P<0.05);观察组与对照组肝肾功能水平和不良反应发生率比较均无差异(P>0.05)。结论:依托考昔治疗急性痛风性关节炎患者可明显改善关节病变,不增加肝肾功能损伤,有较好的应用安全性和有效性。Objective:To study clinical effects of joint lesion and liver-kidney function in acute gouty arthritis patients with etoricoxib.Methods:A total of 120 consecutives as acute gouty arthritis from June 2016 to June 2017 were enrolled and divided randomly into control and observation groups,each of 60 cases.The patients in control group received diclofenac sodium 75mg/d and they in observation group adopted etoricoxib 60mg/d,they all got intro-articular corticosteroid injection(compoundbetamethasone3.5mg+2%lidocaine0.5ml+NS.0.5ml)if necessary,the course was 5d;then to compare differences of joint lesion scores including pain,tenderness,swelling,and skin blush before and after treatment 1d,3d,5d;the levels of serum uric acid,ESR,C reactive protein(CRP)and white blood cell,liver function(ALT),kidney function(serum creatinine)and complications.Results:The joint lesion scores in the two groups were gradually lower,and they in observation group were significantly less(P<0.05).The levels of uric acid,ESR,CRP and white blood cell after 5d in observation group were significantly lower(P<0.05).The liver-kidney function and complications in the two groups were no statistical differences(P>0.05).Conclusion:It is safe and effective of Etoricoxib for ccute gouty arthritis patients,which can greatly improve joint lesion without increasing liver-kidney function damages.

关 键 词：依托考昔 急性痛风性关节炎 关节病变 肝肾功能 

分 类 号：R589.7[医药卫生—内分泌]