特立帕肽联合氯膦酸二钠胶囊治疗绝经后OP的疗效  

Efficacy of teriparatitide combined with sodium clodronate capsules in treatment of postmenopausal osteoporosis

作　　者：王丽丽 WANG Li-li(Department of Endocrine and Metabolic Diseases,Jiaozuo People’s Hospital,Jiaozuo,Henan 454000,China)

机构地区：[1]焦作市人民医院内分泌与代谢性疾病科,河南焦作454000

出　　处：《医药论坛杂志》2023年第1期74-77,共4页Journal of Medical Forum

摘　　要：目的 观察绝经后骨质疏松症(osteoporosis, OP)联合应用特立帕肽与氯膦酸二钠胶囊治疗的疗效。方法 选择焦作市人民医院收治的绝经后OP患者,总病例数144例,时间2020年3月至2021年10月。随机分为实验组(72例)和对照组(72例)。对照组给予氯膦酸二钠胶囊治疗,在此基础上,实验组给予特立帕肽治疗。治疗前、治疗1年后,比较两组患者腰椎L1~4节段、髋部、脊柱、股骨颈的骨密度;比较骨钙素(BGP)、I型原胶原N-端前肽(PINP)、骨保护素(OPG)、血清转化生长因子β1 (TGF-β1)、白介素-6(IL-6)值;比较预后。结果 治疗1年后,两组患者腰椎L1~4节段、髋部、脊柱、股骨颈四个部位的骨密度;BGP、OPG、TGF-β1均上升,实验组患者比对照组高,差异有统计学意义(P<0.05);两组患者PINP、IL-6均降低,且实验组患者比对照组低,差异有统计学意义(P<0.05);实验组患者不良反应发生率(12.50%)与对照组(9.72%)相比,差异无统计学意义(P>0.05);实验组骨折发生率(4.17%)比对照组(16.67%)低,差异有统计学意义(P<0.05)。结论 绝经后OP联合应用特立帕肽与氯膦酸二钠胶囊治疗,可调节骨密度和骨代谢指标水平,还可降低炎症因子水平及骨折发生率,安全可行。Objective The efficacy of postmenopausal osteoporosis(OP) combined with teriparatide and diodium clodronate capsules was observed.Methods Totally 144 postmenopausal OP patients were admitted into Jiaozuo People’s Hospital from March 2020 to October 2021.They were randomly divided into experimental group(72 cases) and control group(72 cases).The patients in the control group were treated with clodronate capsules, and on this basis, the patients in the experimental group were treated with teriparatide. Before treatment and after 1 year of treatment, the bone mineral density(BMD) of the L1~4 lumbar spine segments, hip, spine and femoral neck were compared between the two groups;The values of bone gla protein(BGP),Type I procollagen N-terminal propeptide(PINP),Seroconversion growth factorβ1(TGF-β1) and Interleukin-6(IL-6) were also compared.What is more, prognoses were compared.Results After 1 year of treatment, the BMD of L 1~4 lumbar spine segments, hip, spine, and femoral neck;BGP, OPG, and TGF-1 were all increased.Patients in the experimental group were higher than those in the control group, with statistically significant difference(P<0.05);The value of PINP and IL-6 were lower in both groups, and the experimental group were lower than the control group, with statistically significant difference(P<0.05);Compared with the control group(9.72%),the incidence of adverse reactions of patients in the experimental group(12.50%) was no statistically significant difference. The incidence of fracture in the experimental group(4.17%) was lower than that in the control group(16.67%), which has statistically significant difference.(P<0.05).Conclusion The combination of postmenopausal OP with triopatide and clodronate capsulecan regulate the level of bone mineral density and bone metabolism indicators, and can also reduce the level of inflammatory factors and the incidence of fracture, which is safe and feasible.

关 键 词：特立帕肽 氯膦酸二钠胶囊 绝经 骨质疏松症 骨代谢 炎症因子 

分 类 号：R589.5[医药卫生—内分泌]