抽提透刺针法针刺联合西药治疗对脑梗死患者功能康复及血清GDF-15、Fibulin-5、UCH-L1表达的影响  

Effect of extraction through needling combined with Western Medicine on functional rehabilitation and serum expression of GDF-15,Fibulin-5 and UCH-L1 in patients with cerebral infarction

作　　者：张小文 黎璐茜 黄浩 薛爱国 王佩光 ZHANG Xiaowen;LI Luxi;HUANG Hao;XUE Aiguo;WANG Peiguang(Department of Rehabilitation Medicine,Dongguan Traditional Chinese Medicine Hospital,Dongguan Guangdong 523127,China;Department of Acupuncture,Dongguan Traditional Chinese Medicine Hospital,Dongguan Guangdong 523127,China)

机构地区：[1]东莞市中医院康复医学科,广东东莞523127 [2]东莞市中医院针灸科,广东东莞523127

出　　处：《新疆医科大学学报》2023年第2期238-243,共6页Journal of Xinjiang Medical University

基　　金：2022年度广东省医学科研基金项目(A2022461)。

摘　　要：目的探讨抽提透刺针法针刺联合西药治疗对脑梗死患者功能康复及血清生长分化因子-15(Growth differentiation factor-15,GDF-15)、衰老关键蛋白抗原-5(Aging key protein antigen-5,Fibulin-5)、泛素羧基末端水解酶-1(Ubiquitin carboxyl terminal hydrolase-1,UCH-L1)表达的影响。方法选取东莞市中医院2019年6月至2020年12月脑梗死患者98例,采用随机数字表法分为研究组与对照组,各49例。对照组常规基础上采取西药治疗(包括氯吡格雷、神经节苷脂、阿托伐他汀治疗),研究组在对照组治疗基础上采取抽提透刺针法针刺治疗。比较两组治疗前后神经功能[美国国立卫生研究院卒中量表(National institutes of health stroke scale,NIHSS)评分、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)]评分、躯体功能[Berg平衡量表(Berg balance scale,BBS)、Burke倾斜量表(Burke tilt scale,BLS)、Sheikh躯干控制量表(Sheikh torso control scale,Sheikh)评估躯体控制能力]评分、日常生活能力(Barthel index,BI)评分、生化指标(GDF-15、Fibulin-5、UCH-L1)水平。结果(1)神经功能:治疗后两组患者NIHSS、MoCA评分较治疗前降低,且研究组患者NIHSS评分低于对照组患者、MoCA评分高于对照组患者,差异有统计学意义(P<0.05);(2)躯体功能:治疗后两组患者BBS、BLS、Sheikh评分与治疗前比较差异均有统计学意义(P<0.05),且研究组患者BLS评分低于对照组患者,BBS评分、Sheikh评分高于对照组患者,差异均有统计学意义(P<0.05);(3)日常生活能力:治疗后两组患者BI评分较治疗前增加,且研究组患者评分高于对照组患者,差异有统计学意义(P<0.05);(4)生化指标:治疗后研究组患者血清GDF-15、UCH-L1水平低于对照组患者,Fibulin-5水平高于对照组患者,差异均有统计学意义(P<0.05)。结论采取抽提透刺针法针刺辅助常规西医治疗脑梗死可取得良好效果,利于改善患者神经功能及躯体功能,可能与有效�ObjectiveTo explore the effects of extraction through needling combined with basic support on functional rehabilitation and serum levels of growth differentiation factor-15(GDF-15),aging key protein antigen-5(Fibulin-5)and ubiquitin carboxyl terminal hydrolase-1(UCH-L1)in patients with cerebral infarction.MethodsA prospective selection of 98 patients with cerebral infarction in the hospital from June 2019 to December 2020 were divided into the study group and the control group,with 49 cases in each group,based on a simple random number table method.On the basis of routine,the control group was treated with Western Medicine(including clopidogrel,ganglioside and atorvastatin),and the study group was treated with extraction and penetrating needling on the basis of the control group.The neurological function(NIHSS,MoCA)score,somatic function(BBS,BLS,Sheikh)score,ability of daily living(BI)score,biochemical index(GDF-15,Fibulin-5,UCH-L1)level and the activation state of the contralateral primary sensorimotor cortex(SMC)of the two groups before and after the treatment were statistically analyzed.Results(1)Neurological function:After the treatment,the scores of NIHSS and MoCA in the two groups were lower than those before the treatment,and the scores of NIHSS in the study group were lower than those in the control group,and the scores of MoCA in the study group were higher than those in the control group(P<0.05).(2)Physical function:the scores of BBS,BLS and Sheikh in the two groups after the treatment were significantly different from those before the treatment(P<0.05);the scores of BLS in the study group were lower than those in the control group;BBS score and Sheikh score were higher in the study group than those in the control group after the treatment;the activation frequency and volume were higher in the study group than those in the control group,the differences were significant(P<0.05).(3)Ability of daily living:after the treatment,the BI score of the two groups were increased,and the BI score of the study group

关 键 词：抽提透刺针法 脑梗死 生长分化因子-15 衰老关键蛋白抗原-5 泛素羧基末端水解酶-1 

分 类 号：R454.9[医药卫生—治疗学]