针刺单穴与配伍腧穴对原发性失眠患者多导睡眠图睡眠参数的影响差异研究  

A comparative study on the difference of acupuncture at combined acupoints or at one single acupoint in improving the polysomnography parameters in patients with primary insomnia

作　　者：曹家桢 莽靖[2] 徐忠信[2] 杜广中[3] 岳公雷[3] 王富春[1] 李铁[1] CAO Jiazhen;MANG Jing;XU Zhongxin;DU Guangzhong;YUE Gonglei;WANG Fuchun;LI Tie(Changchun University of Chinese Medicine,Changchun 130117,China;Department of Neurology,China-Japan Union Hospital,Jilin University,Changchun 130033,China;Qilu Hospital of Shandong University,Jinan 250063,China)

机构地区：[1]长春中医药大学,长春130117 [2]吉林大学中日联谊医院神经内科,长春130033 [3]山东大学齐鲁医院,济南250063

出　　处：《吉林中医药》2023年第3期249-253,共5页Jilin Journal of Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2014CB543100);全国名中医传承工作室建设项目(国中医药办人教函〔2021〕270号)。

摘　　要：目的评估针刺配伍腧穴和单穴在对改善原发性失眠患者多导睡眠参数影响的差异。方法使用中央随机系统将2015年5月-2018年5月3个临床中心门诊和住院的144名原发性失眠患者按1:1:1比例随机分为配伍组、单穴组、非经非穴组,接受不同针刺治疗。3组所有参与者接受5周共25次针刺治疗。所有原发性失眠患者在治疗前和治疗后的第1天22:00至第2天6:00进行多导睡眠检测,并完成匹兹堡睡眠指数(PSQI)和阿森斯失眠量表(AIS)评分。结果共纳入128名参与者,3组的基线期特征具有可比性。配伍组与单穴组PSQI和AIS评分、多导睡眠参数与治疗前相比均有改善(P<0.05)。与单穴组、非经非穴组比较,配伍组PSQI评分显著改善(P<0.01),睡眠总时间、睡眠效率、睡眠潜伏期显著增加(P<0.01,P<0.05),但AIS评分、觉醒时间、觉醒次数、快速眼动睡眠期差异无统计学意义(P>0.05)。结论针刺配伍腧穴可有效改善原发性失眠患者睡眠质量,调整睡眠结构,总体疗效优于针刺单穴治疗。Objective To evaluate the difference of acupuncture at combined acupoints or at one single acupoint in improving the polysomnography parameters in patients with primary insomnia.Methods From May 2015 to May 2018,144 outpatients and inpatients with primary insomnia in 3 clinical centers were randomly assigned to the combined acupoints group,the single acupoint group and the non-acupoint group for a different acupuncture treatment,with 48 cases in each group.All the participants in the three groups received an acupuncture treatment for 25 times in 5 weeks.They underwent a polysomnography test from 22:00 p.m.to 6:00 a.m.on the first day before and after treatment,and completed a test on the Pittsburgh Sleep Quality Index(PSQI)and the Arsens Insomnia Scale(AIS).Results A total of 128 participants were included in the fi nal analysis,and the baseline characteristics were equivalent between the three groups.The PSQI and AIS scores and the polysomnography parameters in the combined acupoints group and the single acupoint group were improved compared with those before treatment(P<0.05).Compared with the single acupoint group and the non-acupoint group,the PSQI score was signifi cantly improved(P<0.01)and the total sleep time,sleep efficiency and sleep latency were significantly increased(P<0.01,P<0.05)in the combined acupoints group,while the differences in the AIS score,awake time,wake after sleep onset and rapid eye movement sleep were not statistically significant(P>0.05).Conclusion Acupuncture at combined acupoints can effectively improve the sleep quality and adjust the sleep structure in patients with primary insomnia,and its overall effect is better than that of acupuncture at a single acupoint.

关 键 词：原发性失眠 配伍腧穴 多导睡眠图 百会 神门 三阴交 

分 类 号：R245.3[医药卫生—针灸推拿学]