TRPV1受体在针刺镇痛中的调节作用及机制研究  

Analgesic effects and mechanisms of acupuncture based on TRPV1 receptor

作　　者：沈海月 詹逸珺 裴建[1] SHEN Haiyue;ZHAN Yijun;PEI Jian(Department of Acupuncture and Moxibustion,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院针灸科,上海200032

出　　处：《吉林中医药》2023年第3期353-357,共5页Jilin Journal of Chinese Medicine

基　　金：上海市进一步加快中医药传承创新发展项目(zy〔2021-2023〕-0209-10)。

摘　　要：TRPV1作为一种新型离子通道,在疼痛调节方面具有重要作用。新型靶向镇痛药物开发遇到挑战,非药物疗法受到越来越多关注。近年来,研究表明TRPV1受体与针刺镇痛疗效高度相关,TRPV1通过上调启动兴奋性pNR1-pCaMKII通路介导针刺信号向中枢神经系统传导而发挥针刺效应。对于各类疼痛,针刺的缓解机制主要以抑制外周、脊髓、中枢及内脏的TRPV1信号表达为主,类似于TRPV1拮抗剂作用。但对于炎性疼痛,针刺对不同脑区TRPV1的调节同时有拮抗和激动,而对于精神性疼痛,则以上调TRPV1信号为主。Chronic pain is one of the major disease burdens in the world.David Julius,the Nobel Prize winner in physiology or medicine in 2021,discovered the capsaicin receptor(transient receptor potential vanilloid subfamily member 1,TRPV1).As a new type of ion channel,TRPV1 is of great significance to pain regulations,but the research and development of new targeted analgesic drugs based on it is facing challenges,and non-pharmaceutical therapy is receiving more and more attention.Recent studies have shown that TRPV1 receptor is highly correlated with the analgesic efficacy of acupuncture,and that TRPV1 exerts acupuncture effects by up-regulating and activating the excitatory pNR1-pCaMKII pathway to mediate the acupuncture signal transmission to the central nervous system.For all kinds of pain,the relief mechanism of acupuncture is mainly based on the inhibition of the TRPV1 signal expression in the periphery,spinal cord,center and viscera,which is similar to the effect of TRPV1 antagonist.However,for inflammatory pains,acupuncture can antagonize and excite the regulation of TRPV1 in different brain regions at the same time,while for mental pains,it mainly up-regulates TRPV1 signals.

关 键 词：TRPV1 针刺镇痛 炎性疼痛 神经病理痛 内脏痛 机制 

分 类 号：R245[医药卫生—针灸推拿学]