妊娠生殖道感染的常见病原体分布临床特点与母婴结局的关系  

The relationship between clinical characteristics of common pathogens distribution and adverse pregnancy outcomes in genital tract infections during pregnancy

作　　者：徐雅斐 鲁玉兵 冉红菊 XU Yafei;LU Yubing;RAN Hongju(Luoyang Maternal and Child Health and Family Planning Service Center Health Care Department for Women;Luoyang Maternal and Child Health Hospital Clinical Laboratory;Luoyang Maternal and Child Health Hospital Obstetrics and Gynecology,Henan Luoyang 471000 China.)

机构地区：[1]洛阳市妇幼保健计划生育服务中心妇女保健科 [2]洛阳市妇幼保健院检验科 [3]洛阳市妇幼保健院妇产科,河南洛阳471000

出　　处：《实验与检验医学》2022年第6期669-672,共4页Experimental and Laboratory Medicine

基　　金：河南省卫计委课题,编号2019027429。

摘　　要：目的确定下生殖道感染(Lower genital tract infections,LGTI)的常见病原体分布及其与不良妊娠结局的关系。方法选择2016年5月至2019年5月在本院检出LGTI的207例妊娠晚期孕妇和未检出LGTI的200例妊娠晚期孕妇作为研究对象。从每个孕妇中收集阴道液,并对引起LGTI的典型病原菌进行微生物学研究,包括细菌性阴道病(BV)、解脲支原体(UU)、阴道毛滴虫(TV)和沙眼衣原体(CT)。应用多元logistic回归模型检验了LGTI(BV、CT、UU、TV)与各不良妊娠结局的相关性。结果在207例LGTI孕妇中,检出160例UU病原体,占77.3%;6例CT病原体,占2.9%;10例TV,占4.8%;64例BV,占30.9%。与对照组相比,LGTI组孕妇中胎膜早破、早产、产褥感染的人数显著增加(P<0.05)。LGTI组新生儿的出生体重显著低于对照组(P<0.05),并且低出生体重和新生儿感染的人数显著增加(P<0.05)。多因素分析显示,UU感染与胎膜早破(OR=3.94)、产褥感染(OR=1.72)、低出生体重(OR=2.29)、新生儿感染(OR=2.29)密切相关(P<0.05);CT感染与早产(OR=16.40)密切相关(P<0.05);TV感染与胎膜早破(OR=4.30)、产褥感染(OR=2.19)、新生儿感染(OR=2.36)密切相关(P<0.05);BV感染与胎膜早破(OR=2.58)、早产(OR=2.01)、产褥感染(OR=2.28)、低出生体重(OR=2.28)、胎儿窘迫(OR=1.72)、新生儿感染(OR=1.68)密切相关(P<0.05)。结论UU、CT、TV和BV是引起妊娠期间LGTI的主要病原菌,并与不良妊娠结局的发生密切相关。Objective The aim of this study was to investigate the relationship between clinical characteristics of pathogens distribution and adverse pregnancy outcomes in genital tract infections during pregnancy.Methods The study selected 207 pregnant women who were diagnosed with LGTI and 200 pregnant women who were not diagnosed with LGTI in our hospital as subjects from May 2016 to May 2019.Vaginal fluid was collected from each pregnant woman and microbiological studies were carried out on typical pathogens causing LGTI,including bacterial vaginosis(BV),Ureaplasma urealyticum(UU),Trichomonas vaginalis(TV)and Chlamydia trachomatis(CT).Multivariate logistic regression models tested the association of individual LGTI(BV,CT,UU,TV)with each adverse pregnancy outcomes.Results Among 207 LGTI pregnant women,160 UU pathogens were detected,accounting for 77.3%;6 cases were CT pathogens,accounting for 2.9%;10 cases were TV,accounting for 4.8%;64 cases were BV,accounting for 30.9%.Compared with the control group,the number of premature rupture of membranes,premature delivery,and puerperal infection was significantly increased in the LGTI group(P<0.05).The birth weight of neonates in the LGTI group was significantly lower than that in the control group(P<0.05),and the number of low birth weight and neonatal infections was significantly increased(P<0.05).Multivariate analysis showed that UU infection was closely related to premature rupture of membranes(OR=3.94),puerperal infection(OR=1.72),low birth weight(OR=2.29),neonatal infection(OR=2.29)(P<0.05);CT infection was closely related to premature delivery(OR=16.40)(P<0.05);TV infection was closely related to premature rupture of membranes(OR=4.30),puerperal infection(OR=2.19).Infection of newborn(OR=2.36)was closely related(P<0.05);BV infection was closely related to prema ture rupture of membranes(OR=2.58),premature delivery(OR=2.01),puerperal infection(OR=2.28),low birth weight(OR=2.28),fetal distress(OR=1.72),neonatal infection(OR=1.68)(P<0.05).Conclusion UU,CT,TV and BV are the

关 键 词：妊娠 下生殖道感染 妊娠结局 病原体 

分 类 号：R714[医药卫生—妇产科学]