1型神经表皮生长因子样蛋白相关膜性肾病合并烟雾综合征1例并文献复习  

Neural epidermal growth factor-like 1 protein-related membranous nephropathy complicated with moyamoya syndrome:a case report and literature review

作　　者：周巧丹[1] 朱凤鸣 曾锐[1] Zhou Qiaodan;Zhu Fengming;Zeng Rui(Department of Nephrology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肾内科,武汉430030

出　　处：《中华肾脏病杂志》2023年第2期135-138,共4页Chinese Journal of Nephrology

摘　　要：膜性肾病是中国除IgA肾病之外最常见的肾小球肾炎,1型神经表皮生长因子样蛋白(neural epidermal growth factor⁃like 1 protein,NELL⁃1)是目前诊断原发性膜性肾病的靶抗原之一。临床和影像表现为烟雾病而可能存在血管狭窄病变的一组综合征被称为烟雾综合征。目前国际上尚无原发性膜性肾病合并烟雾综合征的报道。该文报告1例NELL⁃1相关膜性肾病合并烟雾综合征病例并复习相关文献,为临床诊疗提供依据。Except for IgA nephropathy,membranous nephropathy(MN)is the most common primary glomerulonephritis in China.Neural epidermal growth factor‐like 1 protein(NELL-1)has been currently considered as one of the target antigens for diagnosis of primary MN.Moyamoya syndrome is a syndrome with clinical and imaging manifestations of moyamoya disease and possible vascular stenosis.By far,primary MN complicated with moyamoya syndrome has not been reported internationally.The paper reports a case of NELL-1-related MN complicated with moyamoya syndrome and reviews relevant literature to provide evidence for clinical diagnosis and treatment.

关 键 词：肾小球肾炎 膜性 脑底异常血管网病 诊断 1型神经表皮生长因子样蛋白 

分 类 号：R692[医药卫生—泌尿科学] R743[医药卫生—外科学]