铁死亡在肾纤维化中的作用及机制研究进展  

Research progress on the role and mechanism of ferroptosis in renal fibrosis

作　　者：卓文清 王莉 Zhuo Wenqing;Wang Li(Department of Nephrology,Sichuan Provincial People's Hospital,University of Electronic Science and Technology,Sichuan Clinical Research Center of Kidney Diseases,Chengdu 610072,China)

机构地区：[1]电子科技大学附属医院·四川省人民医院肾内科,四川省肾脏疾病临床研究中心,成都610072

出　　处：《中华肾脏病杂志》2023年第2期145-149,共5页Chinese Journal of Nephrology

基　　金：国家自然科学基金面上项目(81770742);国家自然科学基金区域创新发展联合基金重点项目(U21A20349)。

摘　　要：铁死亡是近来发现的一种非凋亡性细胞死亡类型,主要由铁代谢、活性氧代谢等细胞代谢通路紊乱所导致,其特征是细胞内铁超载和活性氧积聚导致脂质过氧化。铁死亡与肾脏疾病关系密切,在急性肾损伤和肾细胞癌等疾病中作用的研究已广泛开展,同时与肾纤维化的关系也有新的发现与进展。该文从铁死亡的最新调控机制及其在肾纤维化中的作用两方面系统综述铁死亡与肾纤维化的关系,探讨通过靶向抑制铁死亡预防肾纤维化的潜在临床应用前景。Ferroptosis is a recently identified type of non-apoptotic cell death,mainly caused by disruption of cellular metabolic pathways such as iron metabolism and reactive oxygen species metabolism,characterized by intracellular iron overload and reactive oxygen species accumulation leading to lipid peroxidation.Ferroptosis is closely related to renal diseases.The role of ferroptosis in diseases such as acute kidney injury and renal cell carcinoma has been extensively studied,and new discoveries and advances have been made in its relationship with renal fibrosis.The paper systematically reviews the relationship between ferroptosis and renal fibrosis in terms of the latest regulatory mechanisms of ferroptosis and its role in renal fibrosis,and explores the potential clinical application of targeted inhibition of ferroptosis to prevent renal fibrosis.

关 键 词：铁死亡 纤维化 肾功能不全 慢性 过氧化脂质类 铁超载 活性氧 谷胱甘肽过氧化物酶4 

分 类 号：R692[医药卫生—泌尿科学]