乳白肉芝软珊瑚Sarcophyton glaucum的西松烷二萜及生物活性研究  

Cembranoids and their bioactivities in soft coral Sarcophyton glaucum

作　　者：吴敏[1,2] 周开兵 戴好富[2] 曾艳波[2,3] WU Min;ZHOU Kai-bing;DAI Hao-fu;ZENG Yan-bo(School of Horticulture,Hainan University,Haikou 570228,China;Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China;Zhanjiang Experiment Station,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang 524013,China)

机构地区：[1]海南大学园艺学院,海南海口570228 [2]中国热带农业科学院热带生物技术研究所、海南省海洋生物资源功能性成分研究与利用重点实验室,海南海口571101 [3]中国热带农业科学院湛江实验站,广东湛江524013

出　　处：《中国中药杂志》2023年第3期707-714,共8页China Journal of Chinese Materia Medica

基　　金：海南省重点研发计划项目(ZDYF2021SHFZ107);国家自然科学基金项目(41776093);农业农村部财政专项(NFZX2021)。

摘　　要：综合运用各种色谱手段,分离纯化了乳白肉芝软珊瑚Sarcophyton glaucum的化学成分。结合波谱数据、文献数据对比和理化性质等,从中共分离鉴定了9个西松烷型二萜类化合物,分别是sefsarcophinolide(1)、(+)-isosarcophine(2)、sarco-militatin D(3)、sarcophytonolide J(4)、(1S,3E,7E,13S)-11,12-epoxycembra-3,7,15-triene-13-ol(5)、sarcophytonin B(6)、(-)-eunicenone(7)、lobophytin B(8)和arbolide C(9),其中化合物1为新化合物。生物活性测试结果表明,化合物2~6显示出微弱乙酰胆碱酯酶抑制活性,化合物5对肿瘤细胞K562具有微弱的细胞毒活性。Chemical constituents in soft coral Sarcophyton glaucum were separated and purified by various chromatographic methods. Based on the spectral data, physicochemical properties, and comparison with the data reported in the literature, nine cembranoids, including a new cembranoid named sefsarcophinolide(1) together with eight known cembranoids, namely(+)-isosarcophine(2), sarcomilitatin D(3), sarcophytonolide J(4),(1S,3E,7E,13S)-11,12-epoxycembra-3,7,15-triene-13-ol(5), sarcophytonin B(6),(-)-eunicenone(7), lobophytin B(8), and arbolide C(9), were identified. As revealed by biological activity experiment results, compounds 2-6 had weak acetylcholinesterase inhibitory activity, and compound 5 displayed weak cytotoxicity against K562 tumor cell line.

关 键 词：软珊瑚 Sarcophyton glaucum 化学成分 西松烷型二萜 细胞毒活性 

分 类 号：R284.1[医药卫生—中药学]