五味子化学成分和缓解非酒精性脂肪肝病研究进展  

Research progress on chemical constituents of Schisandra chinensis and its effect on nonalcoholic fatty liver disease

作　　者：穆新路 李斌 邹雨岑 刘久石 张本刚[1] 肖培根[1] 刘海涛[1] MU Xin-lu;LI Bin;ZOU Yu-cen;LIU Jiu-shi;ZHANG Ben-gang;XIAO Pei-gen;LIU Hai-tao(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所、中草药物质基础与资源利用教育部重点实验室,北京100193

出　　处：《中国中药杂志》2023年第4期861-878,共18页China Journal of Chinese Materia Medica

基　　金：中央高校基本科研业务费专项(3332021049)。

摘　　要：五味子是一种传统中草药,主要化学成分有木脂素、三萜、多糖和挥发油类等。临床上常用于治疗心脑血管、肝脏、胃肠道和呼吸系统等疾病。现代药理学研究表明五味子提取物及单体类成分具有降低肝脏脂肪、缓解胰岛素抵抗和抗氧化应激等药理活性,在缓解非酒精性脂肪肝病方面具有良好的应用前景。因此,该文对近年来五味子化学成分及其缓解非酒精性脂肪肝病的研究进展进行综述,以期为五味子治疗非酒精性脂肪肝病的研究提供参考。Schisandra chinensis, a traditional Chinese medicinal herb, is rich in chemical constituents, including lignans, triterpenes, polysaccharides, and volatile oils. Clinically, it is commonly used to treat cardiovascular, cerebrovascular, liver, gastrointestinal, and respiratory diseases. Modern pharmacological studies have shown that S. chinensis extract and monomers have multiple pharmacological activities in lowering liver fat, alleviating insulin resistance, and resisting oxidative stress, and have good application prospects in alleviating nonalcoholic fatty liver disease(NAFLD). Therefore, this study reviewed the research progress on chemical constituents of S. chinensis and its effect on NAFLD in recent years to provide references for the research on S. chinensis in the treatment of NAFLD.

关 键 词：五味子 化学成分 非酒精性脂肪肝病 

分 类 号：R259[医药卫生—中西医结合]