工业大麻地上部分中1个新的二氢芪类化合物  

A new dihydrostilbene from aerial part of Cannabis sativa

作　　者：刘志华 王金兰[1,2,3] 赵英楠 李军 时志春[1,2,3] 王丹 赵明 张树军[1,2,3] LIU Zhi-hua;WANG Jin-lan;ZHAO Ying-nan;LI Jun;SHI Zhi-chun;WANG Dan;ZHAO Ming;ZHANG Shu-jun(College of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China;Heilongjiang Industrial Hemp Processing Technology Innovation Center,Qiqihar 161006,China;Technology Innovation Center of Industrial Hemp for State Market Regulation,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]黑龙江省工业大麻加工技术创新中心,黑龙江齐齐哈尔161006 [3]国家市场监管技术创新中心(工业大麻),黑龙江齐齐哈尔161006

出　　处：《中国中药杂志》2023年第4期985-992,共8页China Journal of Chinese Materia Medica

基　　金：黑龙江省省属高等学校基本科研业务费科研项目(145109513)。

摘　　要：研究工业大麻Cannabis sativa地上部分的化学成分。采用硅胶柱色谱及HPLC等色谱技术进行分离纯化,通过理化性质与波谱数据分析鉴定结构。从工业大麻地上部分的乙酸乙酯萃取物中分离得到13个单体化合物,分别鉴定为3′,5′,4″,2-四羟基-4′-甲氧基-3-甲基-3″-丁烯基对二取代苯乙烷(1)、16R-羟基-9Z,12Z,14E-十八碳三烯酸甲酯(2)、(1′R,2′R)-2′-(2-hydroxypropan-2-yl)-5′-methyl-4-pentyl-1′,2′,3′,4′-tetrahydro-(1,1′-biphenyl)-2,6-diol(3)、β-sitosteryl-3-O-β-D-glucopyranosyl-6′-O-palmitate(4)、9S,12S,13S-三羟基-10E-十八碳烯酸甲酯(5)、苯甲醇-O-β-D-吡喃葡萄糖苷(6)、苯乙醇-O-β-D-吡喃葡萄糖苷(7)、顺-3-己烯葡萄糖苷(8)、α-cannabispiranol-4′-O-β-D-glucopyranose(9)、9S,12S,13S-三羟基-10E,15Z-十八碳二烯酸(10)、尿嘧啶(11)、邻羟基苯甲酸(12)、2′-O-methyladenosine(13)。其中化合物1为新化合物,化合物3为新天然产物,化合物2、4~8、10、13为首次从该属植物中分离得到。The present study investigated the chemical constituents in the aerial part of Cannabis sativa. The chemical constituents were isolated and purified by silica gel column chromatography and HPLC and identified according to their spectral data and physicochemical properties. Thirteen compounds were isolated from the acetic ether extract of C. sativa and identified as 3′,5′,4″,2-tetrahydroxy-4′-methoxy-3-methyl-3″-butenyl p-disubstituted benzene ethane(1), 16R-hydroxyoctadeca-9Z,12Z,14E-trienoic acid methyl ester(2),(1′R,2′R)-2′-(2-hydroxypropan-2-yl)-5′-methyl-4-pentyl-1′,2′,3′,4′-tetrahydro-(1,1′-biphenyl)-2,6-diol(3), β-sitosteryl-3-O-β-D-glucopyranosyl-6′-O-palmitate(4), 9S,12S,13S-trihydroxy-10-octadecenoate methyl ester(5), benzyloxy-1-O-β-D-glucopyranoside(6), phenylethyl-O-β-D-glucopyranoside(7), 3Z-enol glucoside(8), α-cannabispiranol-4′-O-β-D-glucopyranose(9), 9S,12S,13S-trihydroxyoctadeca-10E,15Z-dienoic acid(10), uracil(11), o-hydroxybenzoic acid(12), and 2′-O-methyladenosine(13). Compound 1 is a new compound, compound 3 is a new natural product, and compounds 2, 4-8, 10, and 13 were isolated from Cannabis plant for the first time.

关 键 词：工业大麻 大麻素 二氢芪类 十八碳烯酸 

分 类 号：R284.1[医药卫生—中药学]