75岁及以上老年人外周血内皮祖细胞数量与生存时间的关系  

Relationship between the number of peripheral blood endothelial progenitor cells and survival time in individuals aged 75 and older

作　　者：孔晓冬[1] 安蔚 郝钰莹 李岱[1] 张释双[1] 孙宁[1] 刘丽[2] 张蔷 Kong Xiaodong;An Wei;Hao Yuying;Li Dai;Zhang Shishuang;Sun Ning;Liu Li;Zhang Qiang(Department of Geriatrics,Tianjin Medical University General Hospital,Tianjin Geriatrics Institute,Tianjin 300052,China;Department of Neurosurgery,Tianjin Medical University General Hospital,Tianjin Neurological Institute,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院保健医疗部老年医学科、天津市老年病学研究所,天津300052 [2]天津医科大学总医院神经外科、天津市神经病学研究所,天津300052

出　　处：《中华老年医学杂志》2023年第3期310-315,共6页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(81970085);天津市科技计划项目(18ZXDBSY00090);天津市卫生健康科技项目(ZC20184)。

摘　　要：目的探寻≥75岁老年人外周血循环中内皮祖细胞(EPCs)水平和血液相关指标的关系, 明确该老年人外周血循环的EPCs水平与生存时间的关系。方法募集天津医科大学总医院保健医疗部(老年医学科)2008年收治的≥75岁老年人114例, 采集临床资料, 以2020年12月31日为随访终点, 对入组时不同水平的外周血EPCs数量和血液相关指标以及全因死亡事件的相关性进行评估。结果利用偏最小二乘判别分析(OPLS-DA)模型构建的低、高水平EPCs组血液指标中, D-二聚体(D-Dimer)为潜在分类标志物[变量投影重要性值(VIP)=4.750];不同水平EPCs组血液相关指标红细胞(RBC)、血红蛋白(HGB)、红细胞比容(HCT)、天冬氨酸氨基转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、乳酸脱氢酶(LDH)、D-Dimer的差异有统计学意义(均P<0.05);老年人群的血循环EPCs数量与RBC、HGB、HCT呈正相关, EPCs数量与GGT、D-Dimer呈负相关(r=0.364、0.343、0.336、-0.312、-0.312, 均P<0.05);循环EPCs数量与≥75岁老年人群生存时间正相关(r=0.234, P=0.017)。Logistic回归分析结果显示, 老年人群的EPCs数量、年龄和HCT与12年长期随访的全因死亡事件有关(OR=0.971、1.585、1.231, P=0.013、0.012、0.029)。结论外周血循环中的EPCs可能参与贫血、心肝肾损伤、凝血等多种疾病的进展, EPCs的水平可能对≥75岁老年人群的生存时间产生影响, 年龄和HCT可能为全因死亡事件的危险因素, EPCs数量可能为保护因素。Objective To investigate the relationship between the number of epithelial progenitor cells(EPCs)in peripheral blood and blood parameter values in order to clarify the relationship between peripheral blood EPCs and the length of survival in elderly individuals aged 75 and beyond.Methods Analysis was conducted on 114 individuals≥75 years recruited from the Department of Geriatrics,Tianjin Medical University General Hospital in 2008.Clinical data were collected with December 31,2020 as the end of the follow-up.Associations between peripheral blood EPC numbers,blood parameter values and all-cause mortality were analyzed.Results In low and high EPC groups based on orthogonal partial least squares-discriminant analysis(OPLS-DA),D-Dimer was found to be a potential classification marker[the variable importance in projection(VIP)=4.750],out of a panel of blood tests.Blood parameters such as red blood cells(RBC),hemoglobin(HGB),hematocrit(HCT),aspartate aminotransferase(AST),gamma-glutamyl transferase(GGT),lactate dehydrogenase(LDH)and D-Dimer showed statistically significant differences between groups with different levels of EPCs(all P<0.05).Blood EPC numbers were positively correlated with RBC,HGB and HCT and negatively correlated with GGT and D-Dimer in older individuals(r=0.364,0.343,0.336,-0.312,-0.312,P<0.05 for all).The number of circulating EPCs had a significant positive correlation with survival time in older individuals(r=0.234,P=0.017).Based on the data of the long-term(12-years)follow-up,Logistic regression analysis suggested that the number of EPCs,age,and HCT were associated with all-cause mortality events in older individuals(OR=0.971,1.585,1.231,P=0.013,0.012,0.029).Conclusions EPCs in the peripheral circulation may be involved in the progression of various conditions such as anemia,cardiac,hepatic and renal injury,and coagulation.The number of circulating EPCs may influence the survival of elderly individuals≥75 years.Age and HCT may be risk factors for all-cause mortality events,whereas the number

关 键 词：内皮细胞 生存时间 血液相关指标 

分 类 号：R446.1[医药卫生—诊断学]