儿童急性血源性骨髓炎全身抗生素治疗  

Systemic antibiotic treatment for acute hematogenous osteomyelitis in children

作　　者：邸佳琛 时培晟 高秋明 DI Jia-chen;SHI Pei-sheng;GAO Qiuming(Department of Traumatic Orthopedics,The 940 th Hospital,Joint Logistic Support Force of PLA,Lanzhou 730050,China;First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou730000,China)

机构地区：[1]解放军联勤保障部队第九四〇医院创伤骨科,甘肃兰州730050 [2]甘肃中医药大学第一临床医学院,甘肃兰州730000

出　　处：《中国矫形外科杂志》2023年第4期346-350,共5页Orthopedic Journal of China

摘　　要：急性血源性骨髓炎(acute hematogenous osteomyelitis,AHO)是儿童骨关节感染中最常见的类型之一。及时准确的诊断和早期有效的抗菌治疗是获得良好预后的关键。抗生素的合理使用在该病的治疗中扮演着重要角色。有关抗生素的选择、给药方式及用药疗程等方面,需根据当地的流行病学及耐药模式、疾病的严重程度、致病菌毒力、患儿的基础疾病与免疫状态及其对治疗的反应等诸多因素进行个体化制定。此外,在过去的十几年里,该病的流行病学发生了迅速变化,特别是耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)引起的感染,对治疗提出了新的挑战。Acute hematogenous osteomyelitis(AHO)is one of the most common types of bone and joint infection in children,which should be accurately diagnosed on time and treated early with effective antibacterial drugs to achieve good prognosis.The rational use of an⁃tibiotics plays an important role in the treatment of this disease.The choice of antibiotics,the mode of administration and the course of treat⁃ment should be individualized according to the local epidemiology and drug resistance model,the severity of the disease,the virulence of pathogenic bacteria,the underlying diseases and immunity of children and their response to treatment.In addition,the epidemiology of the disease has changed rapidly in the past decade,especially the infection caused by methicillin-resistant Staphylococcus aureus(MRSA),which poses a new challenge to the treatment.

关 键 词：骨髓炎 儿科 抗生素 治疗 耐甲氧西林金黄色葡萄球菌 

分 类 号：R681.2[医药卫生—骨科学]