Ac-SDKP生物学效应与机制的研究进展  

Review on biological effects and mechanism of Ac-SDKP

作　　者：刘爱东 杨方 Liu Aidong;Yang Fang(Department of Pathology,Tianjin Hospital,Tianjin 300211,China;School of Public Health,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]天津市天津医院病理科,天津300211 [2]华北理工大学公共卫生学院,唐山063210

出　　处：《中华劳动卫生职业病杂志》2023年第2期149-155,共7页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金项目(81972988、81472953、81072254)。

摘　　要：N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸(Ac-SDKP)是由胸腺素β4通过内肽酶-α和脯氨酰寡肽酶连续水解后产生的内源性短肽,具有免疫调节、促进血管生成、肿瘤发生和拮抗器官纤维化的作用。本文根据我们部分研究结果和近年来相关的文献,就Ac-SDKP研究进展进行综述。N-acetyl-seryl-aspartyl-lysyl-proline(Ac-SDKP)is an endogenous short peptide produced through the continuous hydrolysis of Thymosinβ4 by meprin-αand prolyl oligopeptidase.It has the functions of immune regulation,promoting angiogenesis,tumorigenesis and anti-fibrosis in organs.In this paper,according to some our research results and related literatures in recent years,a review of Ac-SDKP research progress was written.

关 键 词：纤维化 Ac-SDKP 肿瘤 

分 类 号：R346[医药卫生—基础医学]