倾向性评分匹配法在疫苗保护效果评价中的应用  

Application of propensity score matching for evaluating vaccine effectiveness

作　　者：黄澳迪 唐林 李平[1] 尹遵栋[1] 王富珍[1] Huang Aodi;Tang Lin;Li Ping;Yin Zundong;Wang Fuzhen(National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国疫苗和免疫》2023年第1期119-123,共5页Chinese Journal of Vaccines and Immunization

基　　金：中国CDC公共卫生应急反应机制的运行(131031001000150001)。

摘　　要：疫苗保护效果(Vaccine effectiveness,VE)评价是疫苗上市后真实世界研究的重要内容。真实世界VE评价中使用倾向性评分匹配法(Propensity score matching,PSM)可以克服在研究设计阶段难以随机化的缺点,有效降低研究中可测量的混杂偏倚,使结果更加可信。本文对PSM的原理、方法、优缺点以及在VE评价中的应用进行了综述,为真实世界VE评价中使用PSM提供方法学参考。Vaccine effectiveness(VE)evaluation is an important part of post-marketing,real-world study of vaccines as they are used.Propensity score matching(PSM),used in the evaluation of realworld VE,can overcome difficulties with randomization at the study design stage,reduce confounding biases,and produce reliable result.In this article,we describe principles,methods,and advantages and disadvantages of PSM and the application of PSM in VE evaluation.We aim to provide a methodological reference for real-world VE evaluation using PSM.

关 键 词：疫苗 保护效果 真实世界研究 倾向性评分匹配 

分 类 号：R331[医药卫生—人体生理学] R186[医药卫生—基础医学]