基于聚类分析探讨儿童难治性抽动障碍中医证型分布研究  

To explore the distribution of TCM syndrome types of refractory tic disorder in children based on cluster analysis

作　　者：徐家宝 张振华 付乾芳 田雨灵 宋颖[1] 赵婷 张喜莲[1] Xu Jiabao;Zhang Zhenhua;Fu Qianfang;Tian Yuling;Song Ying;Zhao Ting;Zhang Xilian(Department of Pediatrics of First Teaching Hospital of Tianjin University of Tranditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院儿科国家中医针灸临床医学研究中心,天津300381

出　　处：《国际中医中药杂志》2023年第3期272-277,共6页International Journal of Traditional Chinese Medicine

摘　　要：目的基于聚类分析探讨儿童难治性抽动障碍的临床特点及证型分布。方法横断面研究。选择2015年10月-2022年1月天津中医药大学第一附属医院小儿脑病专科门诊183例3~18岁难治性抽动障碍患儿,应用Microsoft Office Excel 2016和IBM SPSS Statistics 26.0进行频数描述性分析、系统聚类分析和主成分分析,探讨该病临床特点及证型分布。结果183例难治性抽动障碍患儿的中医症状聚类为6类,得到5类证型,其中类脾虚肝旺夹湿证占比最大(27.32%),后依次为类痰火扰神证(21.31%)、类风热犯肺证(18.03%)、类痰气交阻证(17.49%)、类阴虚夹湿证(15.85%)。结论通过对本院儿童脑病专科门诊难治性抽动障碍患儿相关信息的挖掘与分析,得出该病症的常见中医证型,为其中医辨证分型提供参考。Objective To explore the clinical characteristics and distribution of Tranditional Chinese Medicine(TCM)syndrome types of refractory tic disorders in children based on clustering analysis.Methods A cross-sectional study.183 children aged 3-18 years with refractory tic disorders from pediatric encephalopathy outpatient department of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine who met the inclusion criteria from October 2015 to January 2022 were recruited.Frequency descriptive analysis,systematic clustering analysis and principal component analysis were conducted by Microsoft Office Excel 2016 and IBM SPSS Statistics 26.0 to explore the clinical characteristics and syndrome distribution of the disease.Results The TCM symptoms of 183 children with refractory tic disorders were clustered into 6 categories,and finally 5 types of syndrome were obtained,among which the syndrome of spleen deficiency and liver hyperactivity mixed with dampness accounted for the largest proportion(27.32%),followed by the syndrome of phlegm-fire disturbing spirit(21.31%),the syndrome of wind-heat invading lung(18.03%),the syndrome of phlegm-qi stagnation(17.49%),and the syndrome of dampness and yin deficiency(15.85%).Conclusion Through the mining and analysis of the outpatient information of pediatric encephalopathy in our hospital,the common syndrome differentiation types of refractory tic disorder are obtained,which can provide a reference for the TCM syndrome differentiation types of refractory tic disorder in children.

关 键 词：儿童 抽动障碍 证型分布 聚类分析 

分 类 号：R277.7[医药卫生—中医学]