连花平痤饮合泻黄散加减辅助治疗湿热蕴结证痤疮的临床观察  

Clinical Observation of Lianhua Pingcuo Decoction Combined with Modified Xiehuang Powder in Adjuvant Treatment of Acne with Dampness and Heat Accumulation Syndrome

作　　者：郭红梅[1] 孙纪新[2] 陈艳 GUO Hongmei;SUN Jixin;CHEN Yan(Department of Dermatology,Yangzhong Center for Disease Control and Prevention,Yangzhong 212200,China;Department of Dermato-venereal Diseases,Yangzhong Center for Disease Control and Prevention,Yangzhong 212200,China)

机构地区：[1]扬中市疾病预防控制中心皮肤科,江苏扬中212200 [2]扬中市疾病预防控制中心皮肤性病科,江苏扬中212200

出　　处：《基层中医药》2023年第2期47-53,共7页Basic Traditional Chinese Medicine

摘　　要：目的研究连花平痤饮合泻黄散加减辅助治疗湿热蕴结证痤疮的效果。方法选取2019年10月—2021年8月于扬中市皮肤病防治所就诊的湿热蕴结证痤疮患者60例,按照随机数字表法分为对照组(30例)和观察组(30例)。对照组采用莫匹罗星软膏和异维A酸软胶囊治疗,观察组在对照组基础上加用连花平痤饮合泻黄散加减治疗。治疗8周后,评价两组临床疗效、不良反应,比较治疗前后中医证候评分、皮肤粘脱蛋白质含量、角质层含水量、经皮水分丢失量,以及性激素结合球蛋白(SHBG)、雌二醇(E_(2))、游离睾酮(FT)水平。结果两组总有效率比较,观察组(93.33%)高于对照组(73.33%,P<0.05)。治疗后,两组中医证候评分均较治疗前降低(P<0.01),且观察组中医证候评分低于对照组(P<0.01);两组皮肤粘脱蛋白质含量、经皮水分丢失量、FT水平均较治疗前下降,角质层含水量及SHBG、E_(2)水平均较治疗前升高,差异具有统计学意义(P<0.05),且观察组皮肤粘脱蛋白质含量、经皮水分丢失量、FT水平均低于对照组,角质层含水量及SHBG、E_(2)水平均高于对照组,差异具有统计学意义(P<0.01);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论连花平痤饮合泻黄散加减辅助治疗湿热蕴结证痤疮,可调节性激素,改善皮肤屏障功能,减轻临床症状,提高疗效,且安全性较高,临床可进一步推广应用。Objective To study the effect of Lianhua Pingcuo Decoction combined with modified Xiehuang Powder in the adjuvant treatment of acne with dampness-heat accumulation syndrome.Methods Sixty acne patients with dampness-heat accumulation syndrome treated at Yangzhong Dermatology Prevention and Treatment Institute from October 2019 to August 2021 were selected and divided into a control group(n=30)and an observation group(n=30)according to the random number table method.All patients were treated with mupirocin ointment+isotretinoin soft capsule,while those in the observation group received additional Lianhua Pingcuo Decoction combined with modified Xiehuang Powder.After eight weeks of treatment,the clinical efficacy and adverse reactions of the two groups were evaluated,and the traditional Chinese medicine(TCM)syndrome score,mucin content in the skin,water content of cuticle,transdermal water loss,and the levels of sex hormone binding globulin(SHBG),estradiol(E_(2)),and free testosterone(FT)before and after treatment were compared.Results The total effective rate in the observation group was 93.33%,higher than 73.33%in the control group(P<0.05).After treatment,TCM syndrome scores in both groups were lower than those before treatment(P<0.01),and TCM syndrome score in the observation group was lower than that in the control group(P<0.01).The content of skin mucin,transdermal water loss,and FT levels of the two groups were lower than those before treatment,and the water content of cuticle and the levels of SHBG and E_(2)were higher than those before treatment(P<0.05).The content of skin mucin,transdermal water loss,and FT level of the observation group were lower than those of the control group,and the water content of cuticle and the levels of SHBG and E_(2)were higher than those of the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the adjuvant treatment of acne with dampness-heat accumulation syndrome,Lianhua Pingcuo Decoction

关 键 词：连花平痤饮 泻黄散 痤疮 湿热蕴结证 

分 类 号：R27[医药卫生—中医学]