磁性小口径血管磁-结构耦合理论、仿真分析与测试  

Magnetic-structure coupling theory,simulation analysis and testing of magnetic small-caliber blood vessels

作　　者：刘世海 苗晓丹 陈赫 刘道伟 张子衡 LIU Shihai;MIAO Xiaodan;CHEN He;LIU Daowei;ZHANG Ziheng(School of Mechanical and Automotive Engineering,Shanghai University of Engineering Science,Shanghai 201620,China)

机构地区：[1]上海工程技术大学机械与汽车工程学院,上海201620

出　　处：《河南科技学院学报（自然科学版）》2023年第1期58-72,84,共16页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：国家自然科学基金(52172372,51605277)。

摘　　要：目前所制备的小口径血管在体外大多都是以液体为介质来模拟生理脉动,这会使血管受到的剪切力与血管脉动耦合在一起且血管脉动具有一定的滞后性.为解决这一问题,提出了一种在小口径血管支架中掺杂磁性颗粒的方法,磁性小口径血管支架在充磁之后,在外磁场的控制下可实现与生理脉动相似的脉动功能且脉动具有实时性,配合生物反应容器可实现剪切力与脉动的解耦合.通过COMSOL Multiphysics软件对磁性小口径血管支架磁-结构耦合进行了仿真分析.仿真结果表明:磁性小口径血管支架的脉动位移与支架与永磁体的间距成反比关系,与磁性微粒质量分数成正比关系;磁性血管支架变化位移与管径的百分比在不同条件的组合下,最小为0.1%,最大为17%.基于静电纺丝制备了采用聚己内酯和钕铁硼磁性微粒的2 mm磁性小口径血管支架并进行了测试,测试结果表明:磁性小口径血管支架的仿真数据与实验数据趋于一致,相对误差在5%左右.Most of the small-diameter vascular stents prepared at present use liquid as a medium to simulate physiological pulsation in vitro,which will couple the shear force on the blood vessel with the vascular pulsation,and the vascular pulsation has a certain hysteresis.In order to solve this problem,this paper proposes a method of doping magnetic particles in small-diameter vascular stents.After magnetization,the magnetic small-diameter vascular stents can achieve a pulsation function similar to physiological pulsation and pulsation under the control of an external magnetic field.It has real-time performance,and can realize the decoupling of shear force and pulsation with the biological reaction vessel.The magnetic-structure coupling of small-caliber vascular stents was simulated and analyzed by COMSOL Multiphysics software.The simulation results show that the pulsation displacement of the magnetic small-diameter vascular stent is inversely proportional to the distance between the stent and the permanent magnet,and proportional to the mass fraction of magnetic particles;under the combination of different conditions,the minimum percentage of the change displacement of the magnetic vascular stent to the tube diameter is 0.1%,with a maximum of 17%.Based on electrospinning,a 2 mm magnetic small-caliber vascular stent using polycaprolactone and NdFeB magnetic particles was prepared and tested.The test results show that the simulation data of the magnetic small-caliber vascular stent are consistent with the experimental data,and the relative error around 5%.

关 键 词：静电纺丝 小口径血管 磁性 血管支架 

分 类 号：R318.11[医药卫生—生物医学工程]