检测中性粒细胞趋化性的微流控器件研究进展  

Advances of Microfluidic Devices for Detecting Neutrophil Chemotaxis

作　　者：陈裔 张涛[1] 何政 胡灿康 李远[2] 徐文峰[1] 廖晓玲[1] Chen Yi;Zhang Tao;He Zheng;Hu Cankang;Li Yuan;Xu Wenfeng;Liao Xiaoling(Chongqing Key Laboratory of Nano-Micro Composite Materials and Devices,College of Metallurgy and Materials Engineering,Chongqing University of Science and Technology,Chongqing 401331,China;Yongchuan Hospital of Chongqing Medical University,Chongqing 402177,China)

机构地区：[1]重庆科技学院冶金与材料工程学院重庆市纳微复合材料与器件重点实验室,重庆401331 [2]重庆医科大学附属永川医院,重庆402177

出　　处：《山东化工》2023年第1期60-64,共5页Shandong Chemical Industry

基　　金：重庆市博士后自然科学基金项目:斑马鱼尾静脉血管修剪的血流动力学调控及机制研究(项目编号:cstc2020jcyj-bsh0024);重庆科技学院硕士研究生创新计划项目:基于微流控芯片的快速小儿肺炎分型诊断系统的构建(项目编号:YKJCX2120206);国家级大学生创新训练项目:碳中和节能发光材料多功能荧光分析与制备系统的研制(项目编号:202211551008)。

摘　　要：中性粒细胞的趋化作用在机体免疫中扮演了重要角色,研究中性粒细胞的趋化规律对于免疫性疾病的临床诊治具有重要意义。微流控技术基于其微型化、可控化和集成化等诸多优势为细胞的趋化性研究提供了全新平台。本文就近年来用于中性粒细胞趋化性研究的微流控器件进行分类介绍,比较分析其优缺点,为推进技术革新及产业发展提供重要参考。The chemotaxis of neutrophils plays an important role in organism immunity.Studying the chemotaxis of neutrophils is of great significance for the clinical diagnosis and treatment of immune diseases.Microfluidic technology provides a new platform for cell chemotaxis research based on its many advantages such as miniaturization,controllability and integration.In this paper,microfluidic devices used for neutrophil chemotaxis research in recent years is classified and introduced,and their advantages and disadvantages are compared and analyzed,so as to provide an important reference for promoting technology innovation and industrial development.

关 键 词：中性粒细胞 趋化性 微流控器件 

分 类 号：TQ028[化学工程] R392.9[医药卫生—免疫学]