苯乙基间苯二酚/烟酰胺/海茴香提取物经皮共输送纳米载体美白功效研究  

Whitening Effi cacy Study of Phenylethyl Resorcinol/Nicotinamide/Crithmum Maritimum Extract Whitening Co-delivery Nanocarriers

作　　者：何梦蝶 陈家铃 罗丹 陈丹[2,3] 洪延涵 刘卫[3,4] He Mengdie;Chen Jialing;Luo Dan;Chen Dan;Hong Yanhan;Liu Wei(Zhejiang Yingshu Biological Technology Co.,Ltd.,Zhejiang,311215;Wuhan Bestcarrier Biotechnology Co.,Ltd.,Hubei,430075;National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Hubei,430075;College of Life Science and Technology,Huazhong University of Science and Technology,Hubei,430074)

机构地区：[1]浙江英树生物科技有限公司,浙江311215 [2]武汉百思凯瑞生物科技有限公司,湖北430075 [3]华中科技大学国家纳米药物工程技术研究中心,湖北430075 [4]华中科技大学生命科学与技术学院,湖北430074

出　　处：《当代化工研究》2023年第5期161-163,共3页Modern Chemical Research

摘　　要：研究苯乙基间苯二酚/烟酰胺/海茴香提取物经皮共输送纳米载体(Phe/Nic/Cri-NCs)的体外透皮性能和美白功效。皮肤渗透实验结果表明,活性成分经纳米载体包裹后具有良好的皮肤透过性及皮肤储留能力。细胞功效实验结果表明,与游离活性成分比较,Phe/Nic/Cri-NCs显著抑制酪氨酸酶活性,减少黑色素生成,降低ROS水平,效果优于同剂量游离成分组。研究表明,Phe/Nic/Cri-NCs作为新型美白功效原料具有良好的应用前景。To investigate the in vitro transdermal performance and whitening efficacy of Phenylethyl Resorcinol/Nicotinamide/Crithmum Maritimum Extract Whitening Co-delivery Nanocarriers(Phe/Nic/Cri-NCs).The experimental results of skin permeation showed that the active ingredients had good skin permeability and skin storage capacity after wrapped by nanocarriers.Cellular efficacy experiments showed that Phe/Nic/Cri-NCs significantly inhibited tyrosinase activity,reduced melanogenesis,decreased ROS levels compared to the free active ingredient group with the same dose.The study indicated that Phe/Nic/Cri-NCs have good application prospects as novel whitening efficacy ingredients.

关 键 词：苯乙基间苯二酚/烟酰胺/海茴香提取物 共输送纳米载体 皮肤渗透 美白功效 

分 类 号：TQ[化学工程]