健康人群中膳食营养素摄入与血糖及胰岛素抵抗相关性分析  

Correlation analysis between dietary nutrient intake with blood glucose and insulin resistance in healthy population

作　　者：韩拓 王丽霞[1] 王怡雯 李盈[1] 巩红 张春艳[1] 张岩[1] 李永勤[1] 王聪霞[1] Han Tuo;Wang Lixia;Wang Yiwen;Li Ying;Gong Hong;Zhang Chunyan;Zhang Yan;Li Yongqin;Wang Congxia(Department of Cardiology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Health Management,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院心血管内科,陕西西安710004 [2]西安交通大学第二附属医院健康管理部,陕西西安710004

出　　处：《临床荟萃》2023年第2期126-131,共6页Clinical Focus

基　　金：国家自然科学基金资助项目STING-IRF3信号轴介导细胞焦亡在心肌缺血/再灌注损伤中的作用及机制研究(82100359)。

摘　　要：目的探讨人群中不同膳食营养素摄入与血糖及胰岛素抵抗之间的相关性。方法基于中国健康与营养调查数据,通过ID匹配基本人口学资料与血清学检测结果,纳入1376名健康人群数据,分析不同营养素摄入组间空腹血糖差异及与胰岛素抵抗指标相关性。结果糖尿病前期与糖尿病组总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)及血尿酸明显升高,糖尿病组升高更为显著,差异具有统计学意义(均P<0.05)。脂肪摄入量最高四分位组较摄入最低四分位组的空腹血糖显著升高(5.38±1.34 vs 5.06±1.10 mmol/L,P=0.017);空腹血糖与脂肪摄入量呈显著正相关(r=0.1122,P<0.01),而与碳水化合物和蛋白摄入量之间无相关性(均P>0.05)。此外,脂肪摄入还与胰岛素抵抗指标HOMA-IR正相关(r=0.0525,P=0.051),而与胰岛素敏感性指标HOMA-IS及β细胞功能指标HOMA-β负相关(r=-0.0520,P=0.053;r=-0.0681,P=0.011)。结论健康人群膳食中脂肪摄入与血糖升高及机体胰岛素抵抗的发生相关,具体机制有待进一步探究。Objective To explore the correlation between the intake of different dietary nutrients with fasting blood glucose(FBG)and insulin resistance(IR).Methods Based on the data of the China Health and Nutrition Survey(CHNS),the data of 1376 samples were included by matching the basic demographic data and serological test results with ID.The differences in fasting blood glucose of people with different nutrient intake groups,and their correlation with IR indexes were analyzed.Results Serum total cholesterol,triglyceride,LDL-C and serum uric acid in prediabetes group and diabetic group significantly increased,especially in the latter group(P<0.05).FBG was significantly higher in the highest quartile of fat intake group than that in the lowest quartile of fat intake group(5.38±1.34 vs 5.06±1.10 mmol/L,P=0.017).It was positively correlated with fat intake(r=0.1122,P<0.01),but not correlated with carbohydrate and protein intake(both P>0.05).In addition,fat intake was correlated with Homeostatic model assessment of insulin resistance(HOMA-IR)(r=0.0525,P=0.051),and negatively correlated with the Homeostatic model assessment of insulin sensitivity(HOMA-IS)(r=-0.0520,P=0.053)and Homeostasis model assessment for beta-cell function(HOMA-β)(r=-0.0681,P=0.011).Conclusion Fat intake is closely correlated with the increased FBG and IR in healthy population,although the specific mechanism needs to be further explored.

关 键 词：糖尿病 空腹血糖受损 膳食营养素 胰岛素抵抗 脂肪摄入 

分 类 号：R589.2[医药卫生—内分泌]