高血压伴原因未明低钾血症患者临床资料及血清中炎症因子分析  

Analysis on clinical data and inflammatory factors of patients with hypertension complicated with unexplained hypokalemia

作　　者：陈洁[1] 田丹丹[1] 张晨 黄琦 郭林雅 张丽娟[1] 刘芷兰 刘敏[1] CHEN Jie;TIAN Dandan;ZHANG Chen;HUANG Qi;GUO Linya;ZHANG Lijuan;LIU Zhilan;LIU Min(Department of Hypertension,Henan University People′s Hospital(Henan Provincial People′s Hospital),Zhengzhou 450003;Department of Hypertension,Zhengzhou University People′s Hospital(Henan Provincial People′s Hospital),Zhengzhou 450003;Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南大学人民医院(河南省人民医院)高血压科,郑州450003 [2]郑州大学人民医院(河南省人民医院)高血压科,郑州450003 [3]河南中医药大学,郑州450046

出　　处：《郑州大学学报（医学版）》2023年第2期196-200,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金面上项目(82270463)。

摘　　要：目的:探讨高血压伴原因未明低钾血症患者在低钾状态下高血压过程中炎症因子的变化情况。方法:依据纳排标准,选取242例高血压伴原因未明低钾血症患者(观察组)及257例原发性高血压合并血钾正常(4.0~4.5 mmol/L)的患者(对照组)。对比分析两组患者临床资料及靶器官损害情况,应用ELISA法检测并对比两组患者(各16例)血清炎症因子(促炎因子:IL-1β、TNF-α、IL-6、IL-8;抗炎因子:TGF-β1、IL-10)的表达情况。结果:与对照组相比,观察组患者年龄更低[(50.01±13.92)岁vs(46.34±12.22)岁,P=0.002],BMI更高[(22.99±2.71)kg/m^(2)vs(26.16±3.32)kg/m^(2),P<0.001],尿微量白蛋白更高[3.01(0,10.80)mg/L vs 8.8(1.24,28.42)mg/L,P<0.001],外周动脉及靶器官损害更重(P<0.05);低钾状态下,外周血中炎症因子如IL-1β、IL-6、IL-8、TGF-β1、TNF-α表达增加(P<0.05),IL-10表达低于对照组(P<0.001)。结论:低钾状态可能诱导机体炎症因子分泌增加,炎症反应更明显,促进高血压伴原因未明低钾血症患者外周动脉硬化及靶器官损害的发生。Aim:To investigate the inflammatory changes in the process of hypertension in patients with hypertension and unexplained hypokalemia.Methods:According to the criteria of inclusion and exclusion,242 cases of hypertension with unexplained hypokalemia(observation group)and 257 cases of essential hypertension with normal potassium(4.0-4.5 mmol/L)(control group)were selected.Clinical data and damage to target organs of the two groups were compared and analyzed,and the levels of serum inflammatory factors(pro-inflammatory cytokines IL-1β,TNF-α,IL-6,IL-8;anti-inflammatory cytokines TGF-β1,IL-10)in two groups(16 cases each)were determined and compared by ELISA method.Results:Compared with the control group,the observation group was younger[(50.01±13.92)years vs(46.34±12.22)years,P=0.002],BMI was higher[(22.99±2.71)kg/m^(2) vs(26.16±3.32)kg/m^(2),P<0.001],urinary microalbumin was higher[3.01(0,10.80)mg/L vs 8.8(1.24,28.42)mg/L,P<0.001],and the peripheral arteries and target organs were more severely damaged(P<0.05).The levels of serum inflammatory factors such as IL-1β,IL-6,IL-8,TGF-β1 and TNF-αwas significantly increased in the observation group(P<0.05),while the content of IL-10 was significantly lower(P<0.001).Conclusion:The low potassium state may induce increased secretion of inflammatory factors and more severe inflammatory response,promoting peripheral atherosclerosis and target organ damage in patients.

关 键 词：高血压 低钾血症 靶器官损害 炎症反应 炎症因子 

分 类 号：R544.1[医药卫生—心血管疾病]