河南省首例人感染H5N6禽流感病例的流行病学及临床特征  

Epidemiological and clinical characteristics of the first case of human infection with H5N6 avian influenza virus in Henan Province

作　　者：聂轶飞[1] 赵升[2] 朱琳 僧明华[2] 杨凯朝 王海峰[1] 徐瑾[2] 马红霞[1] 叶莹[1] 黄学勇[1] 郭万申[3] NIE Yifei;ZHAO Sheng;ZHU Lin;SENG Minghua;YANG Kaichao;WANG Haifeng;XU Jin;MA Hongxia;YE Ying;HUANG Xueyong;GUO Wanshen(Institute for the Prevention and Control of Infectious Diseases,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016;Institute of Immunization Prevention and Program,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016;Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016)

机构地区：[1]河南省疾病预防控制中心传染病预防控制所,郑州450016 [2]河南省疾病预防控制中心免疫预防与规划所,郑州450016 [3]河南省疾病预防控制中心,郑州450016

出　　处：《郑州大学学报（医学版）》2023年第2期255-258,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技厅重大专项(211100311000);河南省中青年卫生健康科技创新领军人才培训项目(YXKC2020006)。

摘　　要：目的:分析河南省首例人感染H5N6禽流感病例的流行病学及临床特征。方法:2022年3月24日,河南省首次报告一例人感染H5N6禽流感确诊病例。参照《人感染动物源性流感预防控制技术指南(试行)》,疾控机构专业人员对病例开展现场流行病学调查,对涉及的工作场所、病例居住地以及禽类来源地等开展环境标本病原检测。结果:患者临床表现主要为高热、咳嗽、呼吸困难,后因呼吸衰竭死亡;病例有明确的禽肉相关暴露史,早期肺泡灌洗液、禽肉及工作场所环境标本H5N6禽流感病毒核酸均为阳性。结论:该例人感染H5N6禽流感病例通过职业暴露感染,未发现人传人的证据。Aim:To analyze the epidemiological and clinical characteristics of the first case of human infection with H5N6 avian influenza virus in Henan Province.Methods:On March 24,2022,the first case of human infection with H5N6 avian influenza virus in Henan Province had been confirmed.According to the Technical Guidelines for the Prevention and Control of Human-to-Animal-borne Influenza(Trial),CDC professionals conducted on-site epidemiological investigation of the case.The environmental samples from the workplace involved,the residence of the cases and the source of poultry were tested for etiology.Results:The main clinical manifestations were high fever,cough and dyspnea,followed by death due to respiratory failure.The case had a clear history of exposure to poultry.Early alveolar lavage fluid,poultry and workplace samples were positive for H5N6 avian influenza virus nucleic acid.Conclusion:The case of human infection with H5N6 avian influenza virus was infected through occupational exposure,with no evidence of human-to-human transmission.

关 键 词：人感染禽流感 H5N6 流行病学特征 河南省 

分 类 号：R183[医药卫生—流行病学]