新精神活性物质N-乙基氟胺酮盐酸盐的结构确定  

The Structural Determination of the New Psychoactive Substance N-ethylfluamine Hydrochloride

作　　者：蒙卫宁 孔凡栋 周丽曼 梁舒婷 何锡超 李承虎 吴明霞 郝祎 叶显文 宋龙 MENG Weining;KONG Fandong;ZHOU Liman;LIANG Shuting;HE Xichao;LI Chenghu;WU Mingxia;HAO Yi;YE Xianwen;SONG Long(Public Security Department of Guangxi Zhuang Autonomous Region,Nanning 530000,China;School of Chemistry and Chemical Engineering,Guangxi Minzu University,Nanning 530000,China;Drug Intelligence and Technology Center of the Public Security Department of Guangxi,Nanning 530000,China)

机构地区：[1]广西壮族自治区公安厅,广西南宁530000 [2]广西民族大学化学化工学院,广西南宁530000 [3]广西壮族自治区公安厅禁毒情报技术中心,广西南宁530000

出　　处：《合成化学》2023年第3期199-203,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(82104034);广西民族大学相思湖青年创新团队项目(2021RSCXSHQN01)。

摘　　要：近期我国部分地区相继出现尚未报道的一个新精神活性物质(New Psychoactive Substance,NPS)作为氯胺酮,氟胺酮替代品滥用情况,其化学结构及理化性质尚不明确,在毒品检验部门检验鉴定过程中易造成漏检,对公共健康和社会安全构成了严重威胁。为了明确此NPS的化学结构,本研究综合运用气相色谱-质谱联用(GC-MS)、高分辨质谱(HR-MS)、紫外光谱(UV)、红外光谱(IR)以及核磁共振(^(1)H NMR、^(13)C NMR和2D-NMR)等技术并结合无机化学手段对在广西玉林缴获的该NPS进行了结构鉴定。最终,该NPS被鉴定为N-乙基氟胺酮盐酸盐,为一新化合物。相关研究结果可为该NPS的检验和鉴定提供数据参考,推动其列管,以减少对社会的危害。A previous unreported new psychoactive substance(NPS)has been abused as a substitute for ketamine and fluamine in some areas of China,recently.Its chemical structure as well as physical and chemical properties are not yet clear.Thus,it is easy to cause missed detections of this NPS in the identification process,posing a serious threat to public health and social security.This study comprehensively used gas chromatography-mass spectrometry(GC-MS),high-resolution mass spectrometry(HR-MS),ultraviolet spectroscopy(UV),infrared spectroscopy(IR)and nuclear magnetic resonance(^(1)H NMR,^(13)C NMR and 2D-NMR)techniques.combined with inorganic chemical method to determine the structure of the NPS captured in Yulin of Guangxi.The NPS was finally identified as a new compound,N-ethylfluoramine hydrochloride.These results can provide data reference for the detection and identification of the NPS,promote its listing,and reduce the harm to society.

关 键 词：新精神活性物质 N-乙基氟胺酮 结构确定 盐酸盐 核磁共振 

分 类 号：TQ463.5[化学工程—制药化工]