钌催化二氢吡嗪脱氢:一种简便合成吡嗪的方法  

Ruthenium-catalyzed Dehydrogenation of Dihydropyrazines:A Facile Approach to Synthesis Pyrazines

作　　者：洪建权 马明玉 曹华鹏 富莹莹 冯瑞龙 赵奎 郑昌戈 HONG Jianquan;MA Mingyu;CAO Huapeng;FU Yingying;FENG Ruilong;ZHAO Kui;ZHENG Changge(School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《合成化学》2023年第3期216-221,共6页Chinese Journal of Synthetic Chemistry

基　　金：中央高校基本科研业务项目(JUSRP22020)。

摘　　要：吡嗪是一类重要的杂环化合物,广泛应用于医药、有机合成和配位化学等领域。本文报道了一种简便,有效合成吡嗪的方法。[RuCl_(2)(p-cymene)]_(2)/KOAc催化二氢吡嗪脱氢,以43%~90%的收率得到多种吡嗪类衍生物2a~2p,采用^(1)H NMR、^(13)C NMR、IR和元素等手段进行表征,确证所得产物为目标化合物。Pyrazines are important heterocyclic compounds,widely used in medicine,organic synthesis and coordination chemistry.Herein,a facile and efficient method for the synthesis of pyrazines is described,where[RuCl_(2)(p-cymene)]_(2)/KOAc catalyzed dehydrogenation of dihydropyrazines to afford various pyrazine derivatives 2a~2p in 43%~90%isolated yields.All of the compounds were confirmed as target compounds by ^(1)H NMR,^(13)C NMR,IR and elemental analysis.

关 键 词：脱氢 吡嗪 二氢吡嗪 C-H活化 钌络合物 简便合成 

分 类 号：O625.632[理学—有机化学] O621.3[理学—化学]